视网膜周边屈光状态在动物实验中被发现与近视的形成有关，而在流行病学研究中结果一致性较差。目前周边屈光度的测量方法有无法避免的局限性，测量的误差较大。视网膜周边屈光状态主要由其形态所决定，因此准确量化视网膜形态并探讨其对于近视发病的影响对于明确近视的致病机理至关重要。我们在自行搭建的软件平台上设计了从MRI图像上分割眼球的算法并初步量化了视网膜三维形态参数。本项目拟从已建立的三个儿童近视研究队列中选取研究对象并对研究对象进行三年随访，前瞻性地收集屈光发育数据，旨在：1）确定视网膜三维形态参数与儿童近视发病风险的纵向联系；2）明确在近视形成过程中儿童视网膜三维形态的变化规律；3）筛选出对儿童近视发病有较高预测价值的视网膜三维形态参数；4）阐明视网膜形态变化和其他近视相关的眼球参数变化（如：视网膜厚度、晶状体厚度）的伴行性。本课题可为探讨近视形成的机制提供新的线索，也可有助于优化近视防控策略。

The refractive status of peripheral retina is found to be associated with myopia development in animal models, but the results remain inconsistent in epidemiologic studies. Currently, the measurements of peripheral refraction have unavoidable limitations, leading to large measurement biases. Peripheral refraction is mainly determined by the retinal shape. Therefore, accurate quantization of the retinal shape and understanding its effect on incident myopia is crucial for elucidating the mechanism of myopia development. We have designed an approach on the segmentation of eyeballs from MRI images based on our own software platform and have completed the preliminary analyses on quantifying the three-dimensional parameters of the retinal shape. The current study plans to selected the study participants from three established myopia cohorts on children, follow them up for three years and collect the refractive data longitudinally. The study aims 1) to determine the longitudinal association of three-dimensional parameters of the retinal shape and incident myopia among children; 2) to understand the changing patterns of three-dimensional parameters of the retinal shape during myopia development; 3) to identify the most predictive three-dimensional parameter related to incident myopia and 4) to assess the concomitant relationship between changes in retinal shape and other myopia-related ocular parameters such as retinal thickness and lens thickness. The implementation of the study would provide new clues to the mechanism of myopia development and help to optimize the strategies regarding myopia prevention.