分心木为核桃果内木质中隔，作为药材有多种用途但系统与深入研究有限。云南核桃产业在种植面积、产量和产值上均居全国首位，年产核桃已达70万吨以上，分心木作为副产品年产量900万公斤以上，资源蕴藏量异常巨大，但未能有效开发利用。为深入了解分心木的药用价值，寻找分心木资源现代化利用途径，本课题拟以分心木传统药用方式为依据，对分心木进行相关药用基础研究。传统上分心木主要用于治疗中医学肾虚相关的泌尿与生殖系统病症，包括（肾虚）遗精、前列腺疾患、肾炎、淋病尿血等。本课题前期研究结果显示，分心木在抗菌消炎、男性保健等方面确有较好的发展潜力，同时还首次发现分心木可能存在一定的使用安全风险。为此，本课题将在此基础上，围绕分心木品质、安全性、用于生殖与泌尿系统病症功效方面展开系统的化学、毒理学、药效学基础性研究，以期对分心木基本品质与传统应用有深入的认识，为合理开发与科学利用云南巨大的分心木资源提供基础研究依据

Diaphragma Juglandis Fructus (DJF) is the wood compartment of walnut fruit. It was used as an herbal medicine with a variety of uses for a long time, but the systemic and deep study about DJF is limited. Yunnan walnut industry concerning the planting area, yield, and output value ranks first in the country, with an annual output of more than 700,000 tons of walnut, and as a by-product, DJF annual output of more than 9 million kilograms. DJF resource reserves are unusually large. However, most of them are unable to be effectively developed and used. In order to better understand the medicinal value of DJF and find a way for modernized use of DJF resources, based on the traditional medicinal way of DJF, this subject plans to carry out the relevant medicinal basic research on the DJF from Yunnan. Traditionally, DJF is mainly used for the treatment of the urinary and reproductive system diseases due to kidney deficiency, including (kidney deficiency) nocturnal emission, prostate disease, nephritis, and gonorrhea hematuria. The preliminary studies of this project indicated that DJF did possess a good development potential in the anti-bacteria, anti-inflammatory, and male health. Moreover, we also found for the first time that when DJF is used as an herbal medicine, possible safety risk may exist. For the purpose to comprehensively and systematically understand the quality of DJF, as well as the rationality of traditional application of this medicine, this project plans to conduct a series of chemical, toxicological, and pharmacodynamic research about DJF focused on the quality, safety, and the efficacy for reproductive and urinary system disorders. We hope this project could lay an important foundation for the rational development and scientific use of huge DJF resources from Yunnan in the future.