申请人在等离激元纳米材料的制备、光学属性及其表面增强拉曼光谱和生物医学领域的应用取得具有特色的研究成果：（1）制备出系列光学属性高度可调的非对称性等离激元纳米结构；（2）观察到激元反键模式，为激元杂化理论提供实验佐证；（3）首次设计Fano 结构用于高灵敏度拉曼检测；（4） 结合表面拉曼增强光谱技术和多元统计方法实现单细胞肺癌细胞亚型的区分；（5）制备单层和多层核壳亚纳米缝隙增强拉曼探针，发现需引入量子效应来解释其光学属性。申请人在Nano Lett. (4), ACS Nano (2), Small (1), J. Mater. Chem. A (1), Nanoscale (4), Chem. Commun. (1)等期刊发表论文46篇（30篇IF>3，H因子18，他引>760，单篇他引约150）。本项目旨在制备多功能的缝隙增强拉曼载药探针，推动其在脑胶质瘤的术中成像和治疗应用。

The applicant has made some achievements about plasmonic nanostructures’ fabrication, optical properties investigation, and their applications in the surface enhanced Raman scattering (SERS) and biomedical field including: (1) fabrication of a series of asymmetrical plasmonic nanostructures with highly tunable optical properties via the combination of top-down and bottom-up method; (2) discovering the anti-bonding mode in silver nanorings, as the first experimental proof of anti-bonding mode in plasmon hybridization theory; (3) first time fabrication of plasmonic Fano structures for SERS with the utilization of strong near-field enhancement of the dark mode and bright mode in Fano structures; (4) distinction of subtypes of lung cancer cells by combining intracellular SERS and multivariate statistical method; (5) fabrication of single-shell and multi-shell subnanometer gap-enhanced Raman tags and explaining their near- and far-field optical properties by including quantum plasmon effect. The applicant has published 46 journal papers such as Nano Lett. (4), ACS Nano (2), Small (1), J. Mater. Chem. A (1), Nanoscale (4), Chem. Commun. (1), etc., including 30 papers with IF > 3.0, H index 18, total citation > 950, single paper citation > 150. In this project, the applicant will continue to investigate high-performance multifunctional gap-enhanced Raman & drug tags for brain glioma intraoperative imaging and therapy.