申请人主要从事心肌与神经组织工程研究，在基于工程化心肌组织（ECTs）的构建、体外模型应用、心梗治疗方面取得突破性进展，并在神经组织工程基础与非治疗性应用研究方面形成了特色与优势。主要学术成绩：（1）成功构建了基于导电纳米材料的ECTs，揭示了导电纳米材料通过β1-integrin/FAK/ERK信号通路调控心肌重塑的重要机制；（2）开展ECTs体外非治疗性应用研究，揭示了闰盘组装、心肌细胞去分化等心肌发育与再生相关重大基础科学问题；（3）开展了基于神经组织工程的基础与应用研究，在神经信息解析与智能控制关键技术方面取得重大突破。主持国家自然科学基金、863计划等课题多项，发表SCI论文27篇，第一/通讯作者14篇，影响因子累计57，获授权专利7项。本项目拟针对心梗微环境研制系列功能化修饰的导电性材料，用于构建ECTs并进行心梗修复研究，深入阐明其调控心肌重构与再生修复的规律与机制。

The applicant has been mainly engaging in cardiac muscle and nerve tissue engineering research and making progress especially on construction of engineered cardiac tissues (ECTs), nontherapeutic model applications research in vitro, and myocardial infarction therapy. Besides, in the basic research and nontherapeutic application of nerve tissue engineering possessed unique characteristics. Main academic achievements include: (1) Designed and developed a series of conductive nano materials which were used for construction of engineered cardiac tissue to repair myocardial infarction and has a good therapeutic effect which reveals the important role of beta 1-integrin/FAK/ERK signaling pathway in the myocardial remodeling and regeneration of conductive nano-materials. (2) Carry out the engineered cardiac tissues (ECTs) nontherapeutic applications research, Using fraction model to reveal the intercalated discs assembling process and myocardial cells de-differentiation mechanism of myocardial development and regeneration. (3) Carry out the research on nerve tissue engineering in the field of the basic research and nontherapeutic application, in addition in the primate animal neural information analysis and key technology of intelligent control respect she has made a major breakthrough. As a project leader, she has been funded by the National NaturalScience Foundation, NationalHigh-Tech R&D Program of China (863) and so on. The applicant has authored 27 SCI-indexed papers, 14 papers as first/correspondingauthor with total IF researched 57（including Biomaterials（2）、Sci Rep.（1）、J Cell Mol Med（3））. As a main inventor, she has also obtained 7 Chinese patents. In this proposed project, The applicant plan to focus on fabrication various kinds of functional conductive nano-materials pointed at microenvironment of infarcted myocardium, which can be used to bconstruct ECTs and repair myocardial infarction, and deeply investigat the regularity and mechanism the of myocardium reconstruction and regeneration.