膝骨关节炎（KOA）严重影响中老年人群健康，是老龄化中国社会的重要公共社会问题。大量临床研究显示针刺治疗KOA安全有效，但其作用机制尚不明确，限制了其临床应用和推广。目前研究发现KOA患者大脑下行疼痛调控系统的功能异常，是导致KOA患者临床疼痛症状复杂性的关键病理因素之一。根据“膝为筋之府，筋会阳陵泉”理论，阳陵泉是针刺治疗KOA的经典常用取穴，也是针刺治疗KOA的良好切入点。基于此，本课题将在中医理论的指导下，综合中医学、神经科学、计算机、影像学、心理学等多学科，采用多模态神经成像技术（BOLD-fMRI+ASL）交互印证，使用先进的复杂网络分析方法，引入双模拟设计，从下行疼痛调控系统脑网络整合机制切入，研究针刺阳陵泉对比经典非甾体类抗炎药（塞来昔布胶囊）治疗KOA患者的中枢脑网络整合机制差异，为针刺治疗KOA提供科学依据。

Knee osteoarthritis (KOA) is a major concern of the health in the elderly, which is also a major social public issues in the aging society in China. A large number of clinical randomized controlled trails report that acupuncture treatment is effective and safe for KOA, but the underlying mechanism remains unclear, which restricts its clinical application. It is now well accepted that the abnormity of the descending pain modulatory system in KOA is one of the key pathophysiology for the complex pain symptom in KOA patients. Based on the traditional Chinese medicine (TCM) theory “knee is the converge of Jin, while Yanglingquan acupoint is the coverge of Jin”, Yanglingquan is one of the most frequently used acupoints for KOA and also a good breakthrough point for acupunture treatment for KOA research. Based on the above, this study is projected to integrate neuroscience, computer science, neuroimage and psychology with TCM. Multiple mode neuroimaging techniques (BOLD-fMRI + ASL), advanced complex network analysis method and double dummy design will be combined to investigate the different descending pain modulatory system brain network modulation characteristic between puncturing Yanglingquan acupoint and classic non-steroid anti-inflammatory drug (celecoxib) for KOA treatment, for the sake of providing scientific evidence for acupuncture treatment for KOA.