磁共振成像(MRI)是一种重要的医学影像技术，提高灵敏度是MRI发展的关键问题之一。申请人一直从事超灵敏磁共振的仪器和方法研究，成功应用至肺部等重大疾病，获以下成果：(1)成功研制国内首台动物和人体肺部气体MRI仪器，获中国产学研合作创新成果奖和湖北省2015年度“十大科技事件”；(2)发展了超灵敏MRI新技术：肺癌的多模态分子影像技术、Hyper-SAGE增强信号新方法；(3)应用至活体肺部重大疾病：获得国内首幅哮喘病人肺部气体MRI、对肺癌同时进行成像和治疗。申请人在PNAS、Magn.Reson.Med.、CC等发表论文52篇，授权/受理专利23/20项，成果被MRI诺贝尔奖获得者Mansfield实验室跟进。入选中组部“万人计划”、“湖北青年五四奖章”，中科院“百人计划”结题优秀。申请人拟以自主研制的仪器为基础，进一步发展超灵敏MRI技术对COPD微结构和功能进行可视化和定量研究。

Magnetic Resonance Imaging (MRI) is an important medical imaging technique, and enhancement of MRI sensitivity is one of the key challenges. Applicant keeps focusing on the development of instruments and methodology of ultrasensitive MRI, and has successfully applied to the pulmonary disease studies, achieving the following innovative results: (1) Independently designing and building two ultrasensitive MR instruments: the first domestic gas MRI instrument, and the first domestic ultralow field MR spectrometer; (2) Developing novel methods for in vitro ultrasensitive MRI: multimodal molecular imaging for lung cancer, and Hyper-SAGE technique for enhancing MR sensitivity;(3) Applying to in vivo pulmonary disease MRI: obtaining the first domestic in vivo lung MRI, and lung cancer theranostics. Applicant has published 52 articles in peer-reviewed journals, such as PNAS、Chem. Comm.、Magn.Reson.Med., 23 invention patents, 2 book chapters, and has been appointed as editors for one book and one international journal. The applicant’s scientific result has been followed by the Lab of Sir Peter Mansfield, the MRI Nobel laureate. Evaluation of “Ten Thousand Talent Program” in 2015, “100-Talent Program”was outstanding, “May 4th Youth Medal” of Hubei Province in 2014. If this proposal is funded, applicant will continue developing homebuilt instruments, and apply them to the pulmonary disease study,by coupling with multifunctional and targeted molecular sensors.