癌症发病率日益增高。为有效地阻击癌症，从植物中寻找靶向抗癌药物或活性先导化合物十分紧迫，但"防患于未然"同样重要，且被认为是控制恶性肿瘤的最好办法，天然产物用于癌症的化学预防已成为研究的热点。前期研究发现云南特有植物滇南风吹楠枝叶中富含黄酮类化合物，包括黄酮类中少见的二芳基丙烷类及其醌式二聚体。结合课题组前期在黄酮和苯乙基苷类化合物在化学防癌活性方面的发现，项目拟对云南特有的4种风吹楠属植物的化学防癌及抗肿瘤活性成分进行分离鉴定，用环氧合酶、鸟氨酸脱氢酶、NF-kB抑制等模型评价化合物的化学防癌活性，同时测试化合物HSP90抑制以及细胞毒活性，并探讨其构效关系。本项目拟首次对云南产风吹楠属植物枝叶化学成分进行研究，从中分离鉴定130个以上化合物，为进一步合理利用该属植物提供依据，并从中寻找具有化学防癌活性及抗肿瘤活性的化合物，为进一步的创新药研制奠定基础。

To save people stuggling in the war against cancer, the searching for specific-targeting anti-tumor leads from natural products is always one hotspot. However, "Nip in the bud" is considered to be the best method of treatment of malignant tumor. Natural products for cancer chemoprevention has become another research hotspot. Previous work on the field showed that some phenylethanoid glycosides, flavones, and flavone glycosides are effective. Moreover, the phytochemical investigation on Horsfieldia tetratepala led the isolation of a serial of propanoids and flavones, some of which exhibited selective cytotoxicity. Thus, the project plans to investigate chemoproventive and anti-tumor components from Horsfieldia species indigenous to Yunnan Province. More than 130 compounds would be isolated. Furthermore, cyclooxygenase, ornithine decarboxylase, NF-kB inhibition models would be used to evaluate the chemopreventive effect of those compounds, and HSP90 inhibitive activity and cytotoxity would also be tested. Above results may support the use of those plants in folk medicine, and may support the further innovation in drug development and rational use of resources.