中文摘要
大叶补血草的根(Limonium gmelinii(Willd.)OKuntze)为传统维吾尔医常用药材,在维药复方中应用广泛,历史悠久,疗效显著。又是具有重要经济价值且生态适应力极强的耐盐旱生植物。它具有止血散瘀功效,主治功能性子宫出血,宫颈癌及其他出血。目前在新疆民族医院作为院内制剂使用。其化学成分等方面的研究还欠缺,药材来源复杂,没有质量标准,无法保证药材的质量。本课题组在确定临床用药材的同时,拟用高逆流色谱、制备色谱等现代的快速分离技术对其化学成分进行提取分离和纯化,同时利用现代波谱技术(UV、IR、NMR、MS等)进行结构鉴定,解谱确定化合物结构。同时选择指标性化合物,对其建立特征指纹图谱及质量标准,进一步阐明进口药材与本地道地药材的主成分含量,从而确定维吾尔医用大叶补血草药材。该项目的研究对新疆民族医药的发展和特色药用植物资源的开发利用以及推动地区社会经济建设都具有重要的意义。
英文摘要
Limonium gmelinii (Willd.) Kuntze root is a traditional Uighur medicine,and is widely used in Uighur compound preparation,the long history and a significant curative effect.It is also an important economic value and ecological resilience highly salt and drought tolerant plants.It has a hemostatic efficacy stasis,attending dysfunctional uterine bleeding,cancer and other bleeding. Currently the ethnological hospital in Xinjiang use L.gmelinii as a hospital preparation . Research and other aspects of its chemical composition is also lacking, herbs sources complex , there is no quality standards, can not guarantee the quality of medicines.The research group determine the clinical use of medicines, to separate and purify chemical composition by high counter-current chromatography , preparative chromatography and other modern fast separation technology, while using modern spectroscopic techniques (UV, IR, NMR, MS , etc. ) structural identification , solution spectra to identify the structures . Also select indicator compounds, established its characterized fingerprint and quality standards, and further clarify the main ingredients imported and local Limonium gmelinii herbs . This research has a great maining in the development Xinjiang ethnic medicine and the characteristics utilization the characteristics of medicinal plants resources, as well as promoting regional social economic construction of Xinjiang. .
