本项目拟采用队列研究设计，以前期研究为基础，在中国人群和瑞典人群分别进行食管癌流行病学调查，收集人口学特征、临床信息、环境因素、生活方式等相关信息，并进行遗传易感位点检测，在对食管癌预后相关危险因素进行筛选的基础上，构建食管癌预后预测模型，进一步在中国和瑞典人群中进行相互验证，优化模型参数，最终构建出可用于中国人群和瑞典人群的预后预测模型，并阐明两个人群的异质性。通过这些努力将有助于实现食管癌的个性化的预防、治疗，最终减少人类食管癌的负担。

The project intends to adopt cohort study design, and taking preliminary studies as the basis for the epidemiological investigation of esophageal cancer in Chinese populations and Sweden respectively. We will gather demographic characteristics, clinical information, environmental factors, lifestyle, genetic suscepbility information and other related information. Prognosis model of Esophageal cancer will based on screening results of the risk factors associated with esophageal cancer prognosis in Chinese and Swedish population. The parameters of the final optimal model can be used to construct prognostic models in Chinese and Sweden populations, and to clarify the heterogeneity among these two populations. These efforts will contribute to esophageal personalized prevention, treatment, and ultimately reduce the burden of human esophageal cancer.

本项目采用队列研究设计，以前期研究为基础，对食管癌易感个体进行流行病学调查，收集人口学特征、临床信息、环境因素、生活方式等相关信息，并进行遗传易感位点检测，在对食管癌预后相关危险因素进行筛选的基础上，构建食管癌风险预测模型，通过这些努力将有助于实现食管癌的个性化的预防、治疗，最终减少人类食管癌的负担。