冠心病患者的抑郁障碍患病率高，抑郁障碍是心血管疾病的危险因素。急性心肌梗死并抑郁症患者最常见的证候要素为气虚、血瘀，以“益气逐瘀法”研制的中药制剂参元丹，具有调控炎症反应通路的激活，促进内源性心肌保护的作用。本项目提出如下假说：炎症免疫反应增强与下丘脑-垂体-肾上腺皮质轴功能亢进，影响脑源性神经营养因子表达水平，引起海马神经可塑性的改变可能是其重要的病理基础。拟通过建立急性心肌梗死/抑郁动物模型，测定中药含药血清干预对大鼠的①心肌保护（CK-MB）；②行为模式（体重、敞箱试验、糖水消耗试验）；③致炎性细胞因子水平（TNF-α）；④神经内分泌（5-HT）；⑤神经可塑性（海马形态结构）的作用及影响。揭示益气逐瘀法干预AMI/抑郁症的临床疗效，及其可能的作用机制。

Many studies show high prevalence of depression in patients with coronary artery disease(CAD). While depression disorder also has been identified as a risk factor and a predictor of prognosis for CAD patients. The activation of inflammatory reaction and the hyperfuncting of hypothalamic pituitary adrenal axis (HPA) may have effects on the expression of brain derive neurotrophic factors (BDNF), and lead to changes of neuro-plasticity. This procedure might be an important pathological basis for the concurrency of CAD and depression. Acute myocardial infarction with depression is most common in patients with syndrome factors as Qi deficiency、blood stasis. Shen Yuan Dan (SYD), is Chinese herbal prescription developed on traditional Chinese medicine theory"invigorating qi & dispersing stasis" . It has the endogenous myocardial protective effects, indicationg it may play a role in improving symptoms of CAD patients with depression. Therefore, we plan to establish AMI/depression rats model to observe the effect of SYD on ① myocardial preservation（CK-MB）；② weight and pattern of behavior(open field test、sucrose consumption test)；③proinflammatory cytokines（TNF-α））；④neuroendocrine system（5-HT）；⑤neural plasticity(morphological structure of hippocampus.

冠心病患者的抑郁障碍患病率高，抑郁障碍是心血管疾病的危险因素。急性心肌梗死并抑郁症患者最常见的证候要素为气虚、血瘀，以“益气逐瘀法”研制的中药制剂参元丹 ，具有调控炎症反应通路的激活，促进内源性心肌保护的作用。本项目通过建立急性心肌梗死/抑郁动物模型，测定中药含药血清干预对大鼠心肌保护、行为模式、致炎性细胞因子水平、神经内分泌系统及神经可塑性的作用及影响。项目研究结果发现：参元丹能够保护梗死心肌细胞，增强炎症免疫反应，上调下丘脑-垂体-肾上腺皮质轴功能水平，影响脑源性神经营养因子表达水平，引起海马神经可塑性的改变，从而起到改变AMI/抑郁大鼠行为模式的抗抑郁作用，揭示益气逐瘀法干预AMI/抑郁症的临床疗效及其可能的作用机制。