心房纤维化重构是诱发房颤的结构基础，对心房的电生理及力学特性有重要影响。建模仿真研究具有便利性和可重复性，是对临床研究的辅助手段和必要补充，可广泛应用于心脏功能的评估和心脏疾病机制的研究。本课题拟基于电力学耦合的心房纤维化重构组织模型，研究纤维化对房颤的微观和宏观影响机制。本项目主要研究内容包括：建立完整的心房肌细胞与成纤维细胞的电力耦合模型，研究纤维化对房颤的微观影响机制；建立与实际心房纤维化重构特征相符的组织学模型，通过仿真组织的电兴奋传导和力学形变，研究纤维化重构对房颤的宏观影响机制。本研究通过建立心房纤维重构的组织电力学强耦合模型，阐明纤维化重构对房颤的影响，对加深房颤诱发和维持机制的理解具有重要科学意义，为临床针对心脏纤维化和房颤采取的治疗手段提供新方法和新思路。

Fibrotic remodeling of atrial tissue, which has an important impact on atrial electrophysiological and mechanical characteristics, is a hallmark of atrial fibrillation (AF). In addition to experimental and clinical studies, computer simulations are frequently applied to evaluate the function of heart and investigate the mechanisms of cardiac disease. Based on electromechanical coupled models of fibrotic remodeling of atrial tissue, this research focuses on the influencing mechanisms of fibrotic remodeling to AF. The main contents of this project include: Establish a complete myocyte-fibroblastic electromechanical coupled model to explore micro mechanisms of fibrotic remodeling to AF; Construct a histologic model matched characteristics of atrial fibrotic remodeling to investigate macroscopic influences of fibrotic remodeling on AF through simulation of conduction and deformation. Based on these electromechanical strong coupled models of fibrotic remodeling, this research illustrates the effects of fibrotic remodeling on AF. This study has obvious scientific significance for understanding the mechanism of AF inducement and maintainance. Meanwhile, it provides new idea and new method for treatments of AF and cardiac fibrosis.