体-肺动脉分流术是一种应用于治疗新生儿复杂紫绀型先心病的姑息疗法，被广泛用于复杂先心病合并肺动脉严重发育不良的临床治疗中。术中常采用生物管道或人工管道，但目前对管道直径、长度、吻合位置的选取缺乏客观、精准的判断依据，故易致术后管道扭曲、梗阻、牵拉和肺血流灌注不均衡等问题的发生而引起严重并发症，影响患儿后期手术治疗，研究表明这与分流管内异常血流动力学特性密切相关。.受先前国家自然科学基金支持，本团队成功建立适用于研究Fontan手术血流动力学模拟系统，但其无法同时兼顾多生理因素作用下主动脉和肺动脉血流的特点，也无法研究与血栓形成机制相关的血液流变学非牛顿流体特性。本研究拟通过微尺度PIV流体实验改进计算模拟方法，以开展虚拟手术研究，探索个体化体-肺动脉分流术的最优血流动力学，揭示异常血流动力学因素与管道梗阻、血栓形成机制之间的内在联系，为帮助医生术中选择最佳体-肺动脉分流术分流方案提供参考。

The procedure of the systemic-to-pulmonary shunt is a common and effective method for the children with the severe cyanotic congenital heart diseases. It is a palliative procedure to increase pulmonary blood flow and alleviate cyanosis in surgical planning for the pulmonary atresia, usually serving as the first step of staged procedures. By surgically connected the systemic and pulmonary artery through an artificial conduit, blood from the systemic circulation can flow into the lungs. The surgical technique improved over the years. However, it is still a challenge to select a proper conduit with a suitable length, diameter and anastomosis angle or position to control appropriate distribution of blood flow. Post-operative thrombosis, unbalance lung perfusion and occlusion, distortion of the conduit can be founded to cause severe complications. Numerous researches illustrate the abnormal hemodynamics is suspected to be the main reason around the connection area of the systemic-to-pulmonary shunt...In the previous studies, with the support of National Nature Science Foundation of China, we established a medical image-based computational hemodynamic system for Fontan procedure. However, the system cannot work properly under complex conditions with considering multiple physiological elements in systemic and pulmonary circulations. And also, it cannot be used to investigate the formation of thrombosis caused by hemorheology and its non-Newtonian fluid characteristics. Therefore, we propose to establish a new computational hemodynamic system based on the previous experience and the fluid experiments of Micro-PIV measurements for the study of hemorheology. The new medical image-based computational hemodynamic system and the technique of computer-aided design will be utilized not only to optimize the systemic-to-pulmonary shunt and its application by virtual surgery, but also to disclose the internal relation between the formation mechanism of thrombosis and its local abnormal hemodynamics. The study will improve the understanding of the local hemodynamic characteristics for future treatment in surgical design of the systemic-to-pulmonary shunt.