通过本次交流学习，从药代动力学，药效动力学以及细胞信号调节通路几个方面系统研究导致肾移植受者慢性移植物失功的机制，拟建立联合移植免疫学和药理学的系统的研究方法，分析在欧美人群与中国汉族人群间共性与差异特点，以期提高肾移植受者长期存活时间和生存质量。同时通过本次合作交流，为双方的学科发展搭建良好的国际交流平台。

With this seminar the already existing contacts between the department of Laboratory Medicine of West China Hospital of Sichuan University and the department of Internal Medicine of Erasmus Medical Center Rotterdam can be intensified. On both sides there is an active research program on methods to personalize drug treatment of transplanted patients. At present in patients who have received a kidney transplant tacrolimus and mycophenolic acid concentrations are used to guide the dosage. However, more sophisticated methods, including pharmacodynamic read-outs such as regulatory T-cells or functional assays may provide better ways to assess the impact of drug treatment on alloreactivity and clinical outcome. The seminar would provide an excellent platform to present previous studies in this field performed on both sides, to identify mutual interests and prioritize new targets, and to initiate new studies to further strengthen the collaboration.

按照与荷兰伊拉斯姆斯大学医学中心移植免疫团队的合作交流计划，我们课题组一行5人于2017年4月8日至4月14日在荷兰鹿特丹与荷兰伊拉斯姆斯大学医学中心移植免疫团队进行了为期一周的学术交流合作与讨论。会议期间双方研究者就各自团队研究基础，新进展，拟开展科研合作项目以及共同人才培养计划做了详细的交流，并就现阶段共同关注的课题进行了细致深入的讨论。通过本次交流学习，就双方共同最新的研究进展和思路进行了深入交流，从药代动力学，药效动力学以及细胞信号调节通路几个方面系统研究导致肾移植受者慢性移植物失功的机制，探讨未来开展合作研究的可行性和模式，拟建立联合移植免疫学和药理学的系统的研究方法，分析在欧美人群与中国汉族人群间共性与差异特点，以期提高肾移植受者长期存活时间和生存质量。同时通过本次合作交流，为双方的学科发展搭建了良好的国际交流平台。