申请人长期致力于小脑谷氨酸能神经传递的研究，揭示了多个重要蛋白在突触传递和可塑性、神经元兴奋性以及相关疾病中的作用及机制。申请人的代表性成果包括：揭示了cPLA2α、PICK1、Lgi1等重要蛋白在神经元兴奋性和突触可塑性中的作用，发现了细胞命运决定因子Numb调节代谢型谷氨酸受体以及运动行为，阐明了生理或病理情况下谷氨酸转运体EAAT2，EAAT3和EAAT4的调节机制。这些创新性研究发表在高影响力的期刊Proc Natl Acad Sci USA、J Neurosci、Glia、Neuron、Nat Neurosci等。近五年发表通讯作者论文18篇，包括Proc Natl Acad Sci USA（1篇）和Journal of Neuroscience（2篇）。本课题将围绕前期发现的重要蛋白和分子机制，探讨小脑在运动和精神疾病中的调控机制，为小脑相关疾病的治疗提供新思路。

Focusing on glutamatergic neurotransmission in the cerebellum, the applicant intensively studied multiple key proteins involved in synaptic transmission and plasticity, neuronal excitability and related disorders. The applicant’s representative achievements include: illustrating functions of important signal molecules, including cPLA2α, PICK1 and Lgi1, in neuronal excitability and synaptic plasticity, discovering the regulation of metabotropic glutamate receptor and locomotion by cell fate determinant Numb, and revealing mechanisms underlying the regulations of glutamate transporters EAAT2, EAAT3 and EAAT4 in the physiological or pathological condition. These creative studies have been published in high-profile journals, including Proc Natl Acad Sci USA, J Neurosci, Glia, Neuron, and Nat Neurosci. In recent 5 years, the applicant has published 18 corresponding-author research articles, including Proc Natl Acad Sci USA (1) and J Neurosci (2). Based on key proteins and mechanisms found previously, the present project will examine roles of the cerebellum in locomotion and neuropsychiatric disorders, which will provide new ideas for the treatment of cerebellar related diseases.