申请者主要从事植物与病原真菌相互作用的功能基因组学研究。近5年来，以稻瘟病为研究对象，重点围绕稻瘟病菌的致病机理及水稻抗稻瘟病的分子机制开展系统研究，逐步成为该领域最活跃的青年学者之一，为国内外同行所认可。迄今发表论文22篇（SCI论文13篇），其中以第一作者在Annual Review of Phytopathology、PLoS Pathogens及Plant Cell等著名刊物发表SCI论文5篇（总影响因子41）；参编英文专著2部(2章节)；主持国家自然科学基金项目2项、转基因生物新品种培育重大专项子课题1项，参加国家级项目2项。现任中国植物保护学会青年工作委员会秘书长、北京植物病理学会副秘书长；“Advances in Crop Science and Technology"杂志编委和“Plant Physiology”等多个国际学术期刊审稿人。

My research program centers on functional genomics of plant-pathogenic fungi interaction. During the past five years, I have systemic studied rice blast disease, which focus on the molecular mechanism of rice blast fungus pathogenesis and rice resistance to blast pathogen infection. I have received well recognition from international peers, and became an active young scientist in plant pathology. So far, a total of 22 papers have been published in well-known journals, 13 of them are SCI journals such as Annual Review of Phytopathology, PLoS Pathogens, Plant Cell, with five first author paper (total impact factor of 41). In addition, I have participated in writing two academic monographs (two chapters). I am also the PI on two grants of National Natural Science Foundation of China and a co-PI on a grant of National Major Project of Breeding for New Transgenic Organisms in China, and participated in two national research grants. Currently, I serve as secretary-general of China Society of Plant Protection for Young Scientist, and deputy secretary-general of Beijing Society for Plant Pathology. I am also a editor board member of the Advances in Crop Science and Technology, and reviewers for several SCI journals including the Fungal Genet. Biol., Mol. Plant Pathol., Mol. Plant-Microbe Interact., Plant Physiol., Plant Cell, and J. Phytopathol.

稻瘟病是水稻上最重要的毁灭性病害，威胁着全球粮食安全，每年给全球造成的产量损失可养活6千万人口。因而揭示稻瘟病菌致病机制，可望为稻瘟病防治提供新策略及杀菌剂靶标，具有理论和实践价值。本项目对稻瘟病菌SNARE蛋白胞吞和外泌的机制、bZIP转录因子在该病菌识别寄主表面信号与致病的机制及该病菌进化和变异的机制进行系统研究，取得了以下进展。1）阐明了SNARE蛋白MoSyn8介导胞吞和外泌调控稻瘟病菌致病力的机制；揭示了SNARE蛋白MoSyn8调控的外泌蛋白MoPrs的生物学功能；阐明了胞吞蛋白MoEnd3和MoCAP调控稻瘟病菌致病力的机制。2）解析稻瘟病菌识别寄主表面信号产生功能性附着胞的机制。发现bZIP转录因子调控6个G蛋白信号调控因子的表达，进而控制稻瘟病菌胞内cAMP的含量，从而调控稻瘟病菌识别寄主表面信号，进而控制附着胞形成；发现胞吞蛋白MoEnd3介导的寄主表面信号受体Pth11和Sho1的内化，与细胞骨架蛋白MoCAP共同协调功能性附着胞的形成。3）揭示了稻瘟病菌致病新机制。发现稻瘟病菌转录因子MoAp1上游的蛋白磷酸酶MoYvh1，以及MoAp1的结合蛋白MoTRX2，清除寄主细胞活性氧，促进稻瘟病菌侵染新机制；阐明了bZIP转录因子在稻瘟病菌生长发育和致病过程中的作用机制。4）阐明了稻瘟病菌进化和变异的机制。发现稻瘟病菌除共有的“核心”基因之外，不同菌株拥有特异性效应子，这些效应子是稻瘟病菌变异和进化的重要成因。进一步建立了病菌效应子的鉴定方法，解析了2个新效应分子作用机制，同时解析田间菌株98-06和水稻互作时基因转录模式。上述结果为阐明稻瘟病菌致病分子机理提供重要的试验依据，对解析其他丝状真菌的致病分子机理具有重要指导作用，为开发针对该途径的高效低毒的药剂提供了重要线索。