研究领域为肝癌发生发展分子机制，在国际上率先系统阐述Fox转录因子在肝癌转移中的重要作用（均在国内完成）。①阐明FoxQ1通过招募巨噬细胞浸润调节肿瘤微环境从而促进肝癌转移的机制，首次证实Fox转录因子影响巨噬细胞功能调节肿瘤进展。②通过差异表达和功能筛选阐明FoxC1、FoxM1、和FoxQ1在调节肝癌转移中的不同功能，并系统解析以Fox转录因子为关键节点的上下游信号途径。该研究以Fox转录因子为切入点，为肝癌防治提供新的思路和有效干预靶点。近五年以通讯作者或第一作者在Hepatology(IF=12, 3篇)，第一作者在Journal of Hepatology (IF=9.8)，Oncogene等发表SCI论文9篇，IF总计71.437。5次受邀在美国消化疾病大会做会议发言。拟以炎症到肝癌转化为模型，从肝细胞和巨噬细胞两方面深入研究FoxQ1在炎症到癌转化中的作用及机制。

The applicant focuses on the pathogenesis of hepatocellular carcinoma (HCC) and investigates the mechanism of Forkhead box transcription factor in the regulation of HCC metastasis. (1) The applicant demonstrated for the first time that FoxQ1 promotes HCC metastasis through the recruitment of tumor-associated macrophage infiltration and changing the tumor microenvironment. (2) The applicant first discovered that FoxC1, FoxM1, and FoxQ1 are the most up-regulated genes of Fox gene family in human HCC tissues, and identified the different function and mechanism of FoxC1, FoxM1, and FoxQ1 in regulating HCC metastasis. These findings demonstrated that Fox transcription factors play important roles in the progression of HCC and provided potential therapeutic targets for HCC treatment and diagnosis. In recent five years, the applicant has published nine SCI articles and the total Impact Factor is 71.437. As a corresponding author, the applicant has published one article on Hepatology (IF=11.19, 2015). As a first author, the applicant has published eight articles on Hepatology (IF=12, 2papers), Journal of hepatology (IF=9.858), Oncogene (IF=8.559), etc. The applicant was invited to give oral presentation for five times at the “Digestive Disease Week” in America. The primary purpose of the current project is to investigate the function and possible mechanism of FoxQ1 in inflammation-related HCC, which are going to demonstrate the different function of FoxQ1 in hepatocytes and tumor-associated macrophages.