本群体由裴端卿等5名成员在10余年的合作中自发形成。本群体自2002年开始围绕干细胞多能性维持与体细胞重编程开展研究，主要取得以下学术成绩：1）发现Oct4、Nanog和FoxD3形成负反馈通路并调控多能性的机理；2）率先在我国建立诱导多能干细胞（iPSC）技术及研究体系，并开发出高效率，化学成分确定的iPSC诱导体系；3）在发现过氧化物是诱导iPSC的一大障碍的基础上，揭示维生素C通过调节Jhdm1a/1b、H3K9来克服这一障碍的具体机制；4）发现间充质-上皮转换（MET）是重编程早期的必需步骤，并阐明顺序性EMT-MET在细胞命运转变中的重要作用。2013年该团队以《干细胞多能性与重编程机理研究》获得国家自然科学二等奖。本群体将立足于细胞命运调控中的新理论和新方法，重点开展胚胎干细胞多能性维持、EMT-MET调控多能性获得、多能性退出与分化潜能的建立等相关领域的机制研究。

This group of 5 investigators headed by Prof. Pei has been working together for more than 10 years. Since 2002, this group has been focusing on pluripotency and somatic cell reprogramming and has generated the following insights: 1) discover a negative feedback mechanism including Oct4, Nanog and FoxD3 for pluripotency regulation; 2) establish the first iPSC line and dissimilate the technologies in China, develop a chemical-defined medium for iPSC induction with high efficiency; 3) uncover reactive oxygen species as a barrier for iPSC generation and discover vitamin C as a regulator of histone demethylases, like Jhdm1a/1b, that overcome this barrier; 4) discover MET as an initiating mechanism and a sequential EMT-MET process for optimal iPSC generation. In 2013, a national natural science prize (2nd class) titled onal natural science prize (2a sequential EMT-MET process for optimal iPSC generation. r of histone demet6 years, this group will continue to explore novel mechanisms and methods in cell fate control such as stem cell self renewal, the regulatory roles of EMT-MET on the re-gain of pluripotency, and exit to and establishment of multipotentialities during differentiation.