中文摘要： 铅是一种严重的环境毒和神经毒,低浓度的铅主要影响儿童的智力发育和学习记忆功能.本项目在临床上研究了儿童多动症与血铅含量的相关性；研究了铅对海马神经元突触可塑性、通道、受体的损伤与药物修复机制；研究了铅对海马神经元发育关键期细胞分裂周期蛋白相关激酶 CDKs 的影响；以基因敲除动物为模型，研究铅影响神经系统学习记忆功能信号转导通路的基因调控机理；应用量子点标记技术结合激光共聚焦扫描显微镜技术能连续动态地观察标记的活细胞样品的特性，研究铅引起细胞形态学改变和细胞内大分子的作用位点,建立量子点标记技术在神经毒理学中的应用技术平台，同时研究了量子点的神经毒性和作用机制.通过这些研究,进一步阐明了铅对神经系统学习记忆功能的损伤与修复机理。

Lead is a serious environmental toxicity and neurotoxicity, low concentrations of lead mainly affects children's intellectual development and learning and memory function. This project examined the relationship of Blood lead levels and Attention-Deficit Hyperactivity Disorder in Chinese Children.. We have studied the lead-induced the mechanism of injury and repair of the synaptic plasticity of hippocampal neurons, ion channels and receptors in hippocampus; Lead study the critical period of development of hippocampal neurons associated protein kinase CDKs the cell division cycle; Gene knockout animals as a model to study the lead affect the nervous system of learning and memory function in the signal transduction pathway mechanism of gene regulation; Application of quantum dots labeling technique can be combined for confocal laser scanning microscopy to observe the dynamic characteristics of the sample labeled cells to study cell morphology and cell lead role macromolecules site, creating quantum dot markers in Neurotoxicology of technology platforms; and studied the neurotoxicity and mechanisim of quantum dots.Through these studies, further clarified the lead on learning and memory function in the nervous system injury and repair complex mechanism.

中文摘要： 铅是一种严重的环境毒和神经毒,低浓度的铅主要影响儿童的智力发育和学习记忆功能.本项目在临床上研究了儿童多动症与血铅含量的相关性；研究了铅对海马神经元突触可塑性、通道、受体的损伤与药物修复机制；研究了铅对海马神经元发育关键期细胞分裂周期蛋白相关激酶 CDKs 的影响；以基因敲除动物为模型，研究铅影响神经系统学习记忆功能信号转导通路的基因调控机理；应用量子点标记技术结合激光共聚焦扫描显微镜技术能连续动态地观察标记的活细胞样品的特性，研究铅引起细胞形态学改变和细胞内大分子的作用位点,建立量子点标记技术在神经毒理学中的应用技术平台，同时研究了量子点的神经毒性和作用机制.通过这些研究,进一步阐明了铅对神经系统学习记忆功能的损伤与修复机理。