贴膏剂用热熔压敏胶存在着加工温度高、透湿性差、皮肤刺激性大等问题，其主要原因是骨架材料—苯乙烯系热塑弹性体基质固有的分子结构性问题。本课题设计并通过活性负离子聚合技术精确控制合成PEO-SIS-PEO型热塑弹性体，并通过“桥接”PEO-SIS-PEO改变热熔压敏胶内聚强度，调控热熔压敏胶加工温度与高内聚力间的平衡，实现贴膏剂的高透湿性和低温熔融性，并通过准确表征热塑弹性体和压敏胶的微相结构，揭示“组成—结构—性能”三者之间的关系，从理论上阐明“PEO-SIS-PEO”骨架对药用热熔压敏胶适应性问题。

The hot-melt pressure-sensitive adhesives suitable for emplastrum have disadvantages of high processing temperature, poor moisture permeability and strong skin irritation because their skeleton materials (styrene-based thermoplastic elastomers) have an inherent issue of molecular structures. This project aims at polymerizing PEO-SIS-PEO copolymers via living anionic polymerization with accuracy control, improving the cohesive strength of hot-melt pressure-sensitive adhesives by “bridge-linking” structures, adjusting the balance between their low processing temperature and high cohesive strength, achieving high moisture permeability and low processing temperature, revealing the composition-structure-properties relationship via precisely characterizing the micro-phase structures of hot-melt pressure-sensitive adhesives and thermoplastic elastomers, and theoretically clarifying how the molecular structures of PEO-SIS-PEO copolymers meet the requirement of pharmaceutical hot-melt press-sensitive adhesive.