灯台叶总生物碱对呼吸道疾病显示出良好疗效，起关键治疗作用的是其中的四个生物碱，在治疗中起到协同作用。体内药代研究发现四个生物碱半衰期在1-4小时之间，需要多次频繁给药，因此增强药物的稳定性、延长半衰期，实现缓释并提高药物的生物利用度具有重要的科学意义。项目主要研究内容是针对四个生物碱，用可生物降解材料分别进行化学及物理方法进行同时负载，制备载药纳米胶束材料，通过胶束平衡的破坏及材料的降解逐步释放药物以达到延长药物在体内的半衰期并提高生物利用度的研究目标。化学负载以药物为疏水端、水性降解聚合物为亲水端，通过调整比例在溶液形成纳米胶束；物理包裹方法以聚氨基酸为亲水段，聚酯为疏水段组成的多臂星型两亲性嵌段共聚物为载体，对药物进行负载，制备成载药纳米胶束。本课题的研究为多组分中药纳米复合材料新剂型的制备提供一条科学可行的新思路。研究一类新的药物材料，验证多臂星型嵌聚合物与线性材料相比能否增加载药量

The total alkaloids of the leaves of Alstonia scholaris shows good curative effect on respiratory diseases. The key treatment is the four alkaloids that play a synergistic effect in the treatment. In vivo pharmacokinetic studies have found that four alkaloid half-lives between 1-4 hours, the need for frequent frequent administration. So to enhance the stability of drugs, to extend the half-life, in order to achieve sustained release and improve the bioavailability of drugs has important scientific significance. The main research project is to put four alkaloids, with biodegradable materials for chemical and physical methods for loading. Preparation of nano-drug-loaded materials. Through the destruction of micellar balance and the degradation of the material to gradually release the drug in order to extend the half-life of drugs in the body and improve the bioavailability of research goals. Chemical loading with the drug as the hydrophobic end, the aqueous degradation polymer is the hydrophilic end, by adjusting the ratio in the solution to form nano micelles. The method comprises the following steps: using a multi-arm amphiphilic block copolymer composed of polyamino acid as a hydrophilic segment and a polyester as a hydrophobic segment as a carrier to prepare a drug-loaded nano-micelles. The research of this topic provides a scientific and feasible new idea for the preparation of multi-component nano-composite nanocomposite. A new class of drug materials was studied to verify that the multi-arm star-embedded polymer could increase the drug loading compared to the linear material.