实现口服给药对肿瘤的临床治疗一直是人们努力的方向。但胃肠道障碍及其低靶向性，使得抗肿瘤药难以经口服途径发挥疗效。前期的研究发现肠溶性电纺丝可在肠道高效靶向释放纳米粒，以解决纳米药物的胃肠道屏障。鉴于此本项目：利用全新的poly(mGEG-co-MAA)同轴静电纺丝，在肠道释放多功能载药纳米粒；通过ATRP和开环聚合制备的全新聚合物（FA-DPLADB，δ+），可促进纳米粒在肠道以整体结构形式吸收；“二硫键”的交联作用将提高纳米粒微循环中的稳定性；叶酸基团的引入将提高纳米粒对肿瘤细胞进行主动识别能力；经肿瘤细胞的特异性吸收后，纳米粒的“S-S”键结构可响应胞内及内涵体环境释放药物，实现对肿瘤细胞的高效杀灭，以解决纳米药物靶向性低的问题。本递送体系有机结合了静电纺丝与纳米粒的缓控释优势，有效规避药物口服递送中的诸多问题，实现抗肿瘤药物按组方意图“程序化”递送，为开发口服抗肿瘤制剂提供新途径。

The clinical therapy of cancer via oral administration has been researched all along. However, the barriers of digestive tract and the low tumor-targeting make nano-medicines hard to exert therapeutic effects in cancer cells. In our previous studies showed that the enteric elecrospun fibers (e-fibers) could targeted deliver nanopaticles (NPs) into intestinal tracts. Therefore, in this project, we plan to build an oral anticarcinogen system by integration the multifunctional nanoparticles (multi-NPs) and enterosoluble electropsun nanofibers. The novel poly(mGEG-co-MAA) e-fibers are used to release multifunctional NPs and the intestinal permeation enhancers in intestinal tracts. The novel coolymer obtained (FA-DPLADB，δ+) via ring-opening and ATRP polimerization will promote the multi-NPs to be adsorbed via intestinal epithelial cell and M cells, which avoids the gastrointestinal disorders for nanomedicines. The crosslinking of “S-S” bands improve the biostability of the multi-NPs. Significantly, the immediate induction of folic acid increases the concentrations of multi-NPs in tumor tissues. In cance cells, the “S-S” bands will response to the intercellular environments and release antineoplastic agents, which enhance their treatment effects on tumors. This system combines the release advantages of electrospun fibers and multi-NPs, which “programmatically” release the antineoplastic agents according to the design intent. This project is a basic exploration of oral antineoplastic agent delivery before its clinical application.