发展性阅读障碍（Developmental Dyslexia, DD）是指儿童拥有正常的智力、情感，均等的教育机会和相同的社会文化背景，并排除明显的视听觉和神经系统疾病，但是在阅读方面出现的一种特殊的学习困难状态。在我们前期的流行病学研究发现，新疆维吾尔族儿童阅读障碍的阳性筛查率为7.93%，高于同地区汉族儿童阅读障碍的阳性筛查率(4.69%)。目前，维-汉双语发展性阅读儿童语言加工机制仍不明确。本研究拟采用病例对照研究方法，利用fMRI（功能性磁共振）和ERP（事件相关电位）技术，分别探索在字形、语音、语义以及单字、词语、语句的加工中，相关脑区的血流量变化情况，以及不同加工任务在脑中诱发电位的方向、波幅及时间进程，以了解脑在阅读不同语言时激活的动态变化。本研究将为维-汉双语阅读障碍的神经生物学机制、诊断和干预提供理论基础。

Developmental dyslexia (DD) refers to the children which not only have normal intelligence, emotion and equal educational opportunities ,but also have same social and cultural background. And the obvious audio-visual and diseases of the nervous system were excluded..But,that children have special kind of learning in reading learning difficulties. In our previous epidemiological studies, we found that the positive screening rate was 7.93%, which was higher than that of the Han nationality children in Xinjiang that the positive screening rate was 4.69%. At present, it is still unclear what the language processing mechanism of the Uyghur chinese bilingual children with dyslexia. The purpose of this study is intended a case-control study method which using fMRI and ERP to explore things. The purpose is respectively exploring in shape, pronunciation, semantic and word, term, sentence processing which the blood flow changes and reading about brain regions which related Chinese reading. And the study also explores that the direction, amplitude and duration of evoked potentials in different processing tasks. In order to understand the dynamic changes of the brain during reading, and to analyze the relationship between the brain and reading disorders. This study will provide a theoretical basis for the neurobiological mechanism, diagnosis and intervention of the Uyghur chinese bilingual dyslexia.