申请人基于TRP离子通道和钙稳态，开展血管功能稳态研究，近5年来（1）进一步厘清了小血管舒张因子的性质和来源，解析出高血压发生、发展的新机制（Arterioscler Thromb Vasc Biol 2010 April; Arterioscler Thromb Vasc Biol 2010，Nov；Hypertension 2013）；（2）解析出药物压力条件下血管细胞自我保护措施的形成和细胞间传递的分子机制，为血管稳态失衡早期预警指标的研发提供了新的思路（Proc Natl Acad Sci USA 2014；Proc Natl Acad Sci USA 2012; J Biol Chem 2015）。在此基础上，拟研究（1）TRP通道与血管细胞钙信号基本事件和稳态维持机制；（2）TRP通道与血管生理活动及血管老化关联机制;（3）基于TRP通道的靶向血管保护小分子筛选和优化。

The applicant is mainly engaged in the research of molecular identity of arterial tension, blood pressure regulation and intervention strategies. We have (1) identified that TRP channels are the key molecular mechanisms of artery tension regulation and blood pressure state.(Arterioscler Thromb Vasc Biol 2010 April; Arterioscler Thromb Vasc Biol 2010，Nov；Hypertension 2013); (2) demonstrated TRP channels are responsible for the calcium homeostasis and vascular self-protection (Proc Natl Acad Sci USA, 2014; Proc Natl Acad Sci USA, 2012；J Biol Chem 2015). In the present proposal, we plan to (1) determine the relationship between vascular TRP channels and calcium homeostasis in nano scale. (2) examine the physiological role of vascular TRP channels in vascular system. (3) examine the pathological role of vascular TRP channels in cardiovascular diseases.