申请者主要研究炎症反应在血管病变（动脉粥样硬化及血管瘤）发生发展中的作用。取得成果如下：1）证明免疫球蛋白E（IgE）是促进动脉粥样硬化斑块形成的新炎性分子，提出了IgE及其引起的天然免疫反应可参与心血管疾病发生的新观点。以第一作者发表在J Clin Invest并获述评（Circ Res）。2) 明确钠氯协同转运蛋白是白细胞介素18 的新受体并促进斑块形成，确立了离子交换通道作为炎性细胞因子受体且调控疾病发生的新功能（第一作者 Nat Med）。3）发现调节炎症反应导致血管损伤的新分子（Grx和Melatonin）（J Pine Res 责任作者 回国后工作）。申请者在高水平杂志发表第一作者论文12篇，责任作者论文2篇，曾获美国心血管领域青年科学家奖和哈佛医学院优秀华人科研奖。拟继续探索IgE刺激肥大细胞活化产生的炎症反应在动脉粥样硬化中的调节机制，及其在过敏介导的心血管疾病中的作用。

The applicant’s research is focused on the role of inflammation in the occurrence and development of cardiovascular diseases, including atherosclerosis and abdominal aortic aneurysm. The main findings were: 1) IgE was a novel inflammatory molecule and played a critical role in atherogenesis. This was the first report about the function of IgE-induced inflammation in diseases other than hypersensitivity. These results were published on J Clin Invest and got editorial review comments by Circulation Research. 2) NCC was an alternative receptor of IL18. Our research discovered the novel role of NCC as a cytokine receptor besides the well known iron transporter, which contributed to atherogenesis. 3) The new signaling molecules Grx and Melatonin played important roles in regulating atherogenesis. As a corresponding author, the applicant published these findings that were performed in her own lab in China on J Pine Res. In summary, the applicant has published 12 first author papers and 2 co-corresponding papers on the top 5 journals in the cardiovascular research field. The applicant was ever elected as one of the finalists for Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigators by American Heart Association and won the Harvard Medical School Chinese Distinguish Research Award. The applicant plans to explore the molecular mechanisms of IgE-induced mast cells activation and hypersensitivity in atherogenesis in the following three years.