骨髓增生异常综合征（MDS）的“劳毒”病性特征贯穿于疾病发展与转变的整个过程，课题组根据患者不同阶段病机特征，将其分为“正虚毒蕴”和“毒盛正虚”两大证候类型，分别对应于西医的“相对低危组和“相对高危组）。有研究发现异常的MSC在MDS的发病过程中起着一定作用；Breg是近年新发现的B细胞亚群，在机体免疫网络中扮演着“指挥家”的角色，地位十分重要；同时，最新研究发现，活化的KIR基因与MDS的疾病进展密切相关。本课题通过对MDS及非MDS患者MSC生物学特性、Breg功能、相关细胞因子及活化的KIR基因等指标的检测，明确MSC及Breg/KIR在MDS进展中的作用机制，阐明MDS“劳毒致病”的免疫内涵，建立MDS中医证型的Breg/KIR辨识方程。

Myelodysplastic syndrome character as consumption and poisen,the features always exist in the development and transformation of it's whole process.Our researchers divided it into "deficiency of healthy qi and poison accumulatetion ""poisonous abundan and deficiency of healthy qi",which corresponding to" relative low-risk group" and "relative high-risk group" according to different patients at different stages of disease pathogenesis.Studies have found that the abnormal MSc in the pathogenesis of MDS plays a certain role; Breg is a new discovery of B cell subsets,and plays the role of "conductor" in immune network, its status is very important; at the same time, the latest study found, activating KIR genes and MDS disease progression are closely related. We want to know the mechanisms of MSC and Breg/KIR in the progression of MDS, clarify the MDS "work poisonous pathogenic" immune connotation, Breg/KIR identification equation of MDS TCM syndrome types through detecting of MDS and MDS in patients with non MSC Breg biological characteristics, function, related cytokines and activation of KIR gene index.