申请者一直从事流感病毒的跨种传播和致病机制研究。主要学术成就如下：首次在国际上确认了H7N9和H10N8两种新型禽流感病毒可导致人的感染与死亡; 阐明了H7N9病毒的“双受体”结合特点是其突破种属屏障感染人的重要分子机制，但其在上呼吸道复制效率低是导致病毒不能发生有效人际传播的重要因素；提出了“细胞因子风暴”等因素是导致H7N9感染临床重症的重要原因；进一步提出“基因调频”机制阐明了H7N9的跨种传播过程。首次从分子水平证明活禽市场是导致人感染H5N1禽流感病毒的重要来源。近5年来申请者以第一作者（含共同第一作者）和通讯作者（含共同通讯作者）在Science、Nature、NEJM、Lancet等国际学术期刊上共发表SCI论文48篇（总影响因子379），其中H7N9研究成果同其他课题组一起荣获2013年度中国科学十大进展, 为国家制定H7N9等禽流感防控指南提供了科学依据，发挥了重要作用。

The applicant is engaged in the mechanism study on interspecies transmission and pathogenesis of influenza viruses. His major scientific achievements are including: firstly confirmed human infections with novel H7N9 or H10N8 avian influenza viruses, and identified these two pathogens were associated with fatal cases; The "dual-receptor" binding preference was crucial for the avian influenza H7N9 viruses to cause interspecies transmission and human infection; However the low efficiency of virus replication in human upper respiratory tract limited its sustained human-to-human transmission. "Cytokine storm" was proposed as one of the important contributions to the clinical severity and fatal outcomes of H7N9 patients; A "genetic tuning" mechanism was proposed to mediate host adaptation and interspecies transmission of the H7N9 viruses. Moreover, molecular evidences were firstly provided to link the live poultry markets with human H5N1 infection in China. .In the past five years, a total of 48 peer-reviewed scientific papers (Total SCI IF: 379) with first (including co-first) or corresponding (including co-corresponding) authorship have been published in journals such as Science, Nature, NEJM, Lancet, et al. The scientific achievement of H7N9 viruses was selected as one of the TOP 10 scientific progresses in China in 2013. These studies have also provided essential evidences for the government to develop technical guidelines and played an important role for avian influenza outbreak control and prevention such as H7N9.