功能性消化不良（FD）主要表现为胃肠运动障碍，脑肠肽功能失调为其主要发病机制。至今尚无关于FD的针对性治疗药物，使得该病难以治愈，复发率高。.消化系统疾病是蒙医药学的优势病种之一。传统沙生蒙药沙葱、沙芥在预防和治疗消化不良方面积累了丰富的知识和经验。.课题组前期研究结果表明沙葱、沙芥具有改善FD的作用，但药效物质研究不够深入，作用机制尚待明确。本项目拟在前期工作基础上，总结各类化学成分的质谱裂解规律，结合LC-MS、LC-MS/MS、GC-MS等指纹图谱分析结果，进行药效成分的快速预测、分离与鉴定，综合利用波谱技术确定药效物质的结构；采用与FD发病机制、临床表现相吻合的动物模型及ICC细胞模型，基于改善胃肠动力障碍、调节FD发病核心环节—脑肠肽水平紊乱，阐明沙葱、沙芥改善FD的药效物质及作用机制，指导二者在蒙医药临床的合理应用，为源于临床的民族医药的研发奠定基础，促进沙产业发展。

Functional dyspepsia (FD) mainly shows gastrointestinal motility disorders. It is well known that brain-gut peptide (BGP) dysfunctional is a dominant reason of FD. FD is difficult to cure, with a high recurrent rate. Until now, there is no medication can be used as direct target to FD in clinic..The digestive system disease is one of the supermacy diseases in the Mongolian Medicine. In the prevention and treatment of dyspepsia, traditional arenicolous Mongolian Medicine, Allium mongolicum and Pugionium cornutum have accumulated rich experience and knowledge of promoting gastrointestinal motility and improving indigestion..Previous research results indicated A. mongolicum and P. cornutum had the activity of improving FD. However, the effective substances and mechanism of them are unclear yet. On the basis of preliminary work, this project will summarize the fragmentation pattern of various constituents, combine with LC-MS, LC-MS/MS and GC-MS fingerprint analysis results to carry out a rapid prediction, isolation and identification of effective components in the first; and in the second, the animal model consistent with the pathogenesis of FD and ICC cell model will be used to research the effect and mechanism of improving FD on the basis of regulating the gastrointestinal motility disorder and the core link of BGP level disorder. On the basis of above mentioned experiments, the project will clarify the effective substances and functional dyspepsia-improving mechanism of A. mongolicum and P. cornutum. The results will provide a scientific basis for guiding reasonable application of A. mongolicum and P. cornutum in the clinical Mongolian Medicine and provide the foundation for the development of ethnic medicine from clinical. And which will be benefit for promoting the development of sand industry.