基于前期对《中国药典》记载无毒中药豨莶草毒性作用的系统研究，采用豨莶草为受试药物，完善豨莶草毒性物质提取工艺，解决毒性化合物极易分解的难点，探明豨莶草毒性的物质基础；应用分子生物学技术探索α7nAchR的表达在豨莶草水溶部位药效与毒性中的双向调节作用，系统研究豨莶草的毒性物质和肺毒性的作用机理，并观测剔除豨莶草中毒性物质后豨莶草的药效和用药安全性，为豨莶草的合理应用提供科学依据。

We have conducted a systematic study on Siegesbeckiae which is recorded as non-toxic Herba in Chinese Pharmacopoeia. We will improve the extraction technique to separate the toxic substance of Siegesbeckiae and clarify the material basis of its toxicity. Then we will explore the role of α7nAChR to regulate the efficacy and toxicity of the Siegesbeckiae aqueous portion on molecular levels and the mechanism of pulmonary toxicity of Siegesbeckiae toxic substances. Finally, we will observe the efficacy and drug safety of Siegesbeckiae when toxic substances being removed to provide a scientific basis for reasonable application of Siegesbeckiae.