纳米粒子作为一种影像造影剂和抗肿瘤药物载体，同时实现成像和化疗一体化，为肿瘤的早期诊断及及时治疗提供了可能。但进入循环系统的纳米粒子，极易被网状内皮系统（RES）即肝的Kupffer细胞，脾的吞噬细胞等识别并吞噬，被动地分布于RES分布集中的肝、脾、淋巴等部位，从而降低了纳米粒子的肿瘤靶向性。因而如何提高纳米粒子循环中的递送一直都是研究的热点。本研究在前期研究工作的基础上，进一步优化和发展一种可以调控巨噬细胞吞噬功能的粒子，高效、可逆、可调控的抑制巨噬细胞的吞噬功能，以期显著提高纳米粒子在循环中的半衰期及肿瘤靶向效果。从而扩大纳米粒子的临床应用前景。

Nanoparticles have been intensely pursued for imaging contrast and anti-tumor drug delivery for a long time. The integration of imaging diagnosis and treatment of the nanoparticles would facilitate the nanoparticle’s application in the early diagnosis and tumor treatment. However, their delivery efficiency remains low despite numerous innovations in nanoparticle manufacturing including materials, particle size, surface physicochemistry and targeting moieties. A major reason for this shortfall is their unintended uptake by reticular endothelial system (RES) in the liver, spleen, lung, lymph nodes, etc., which competes with the intended targets. Here we demonstrate a new strategy for manipulation of macrophage function to substantially delay blood clearance and increase tumor accumulation of nanoparticles with different surface properties.