申请人致力于抗肿瘤药物作用机制及创新药物研究，在探索药物调控肿瘤内环境关键蛋白的功能及方式等方面取得系列成果：首次发现肿瘤缺氧关键蛋白HIF-1α可被小分子驱动出核并经自噬溶酶体通路降解的新方式，克服其缺氧入核逃避蛋白酶体降解从而促肿瘤恶性演进的难题，提出基于自噬降解的新型HIF-1α抑制剂的设计理念；首次发现HIF-1α促缺氧肿瘤转移的新下游通路WSB1-RhoGDI2，为对抗肿瘤转移提供新靶点；首次揭示DJ-1介导肿瘤细胞自噬向凋亡转化的信号网络，为自噬/凋亡的转化调控提出新理论，并发现干扰DJ-1功能的抗肿瘤新分子实体。近五年在Cancer Res、Autophagy等国际知名期刊发表25篇通讯作者论文，单篇最高IF为11.4，其它论文49篇，总他引1317次。授权发明专利8项，获浙江省科学技术二等奖3次。将结合前期基础，围绕缺氧肿瘤内环境关键蛋白开展抗肿瘤药物作用及分子机制研究。

The applicant is committed to the development of innovative anti-cancer drugs and the achieving molecular understanding of their action mechanisms. Her work has led to identification of a series of key regulators in tumor microenvironment, and the discoveries of multiple anticancer agents targeting these proteins. Specifically, this applicant has made the following major findings: 1) the applicant has developed the first ever small molecule compound that could promote nuclear exportation of tumor-promoting HIF-1α protein for autophagic degradation, thus introducing a completely new concept and strategy to develop HIF-1α antagonists for chemotherapy; 2)the applicant has uncovered the WSB1-Rho GDI2 axis in regulating cellular response to tumor hypoxia, thus identifying WSB1 as a novel target to prevent hypoxia-associated tumor metastasis; 3) the applicant has identified a novel DJ-1-mediated signaling network in regulating the transition of tumor cells from autophagy to apoptosis and further proposed the development of novel anti-cancer drugs through targeting DJ-1 protein dimerization. In the recent 5 years, as corresponding author, the applicant has published 25 research articles in top journals such as Cancer Research, Autophagy, Antioxidants & Redox signalings, etc., with the highest impact factor reaching 11.4. Totally, her work has been cited 1317 times by other researchers in last five years. Currently, the applicant holds 8 approved national patents. She was also the recipient of three awards for Sci-Tech progress in Zhejiang Province. In the next years to come, this applicant will remain to be dedicated to identification of key proteins or pathways in regulating tumor micro-environment and development of anti-cancer drugs targeting intra-tumor hypoxia.