缺血性心血管疾病已经成为威胁我国乃至世界人类健康的重大疾患，是人类死亡的首因。其发生发展的病理生理和分子生物学机制尚存在诸多不明之处，也缺乏有效的早期防治手段。本创新群体在缺血性心血管疾病的基础研究、应用基础研究和转化医学研究方面开展了一系列长期稳定的合作，特别是在缺血性心血管疾病的重要发病机制如心血管重构的发生发展的炎症免疫、心肌微循环障碍的发生发展、缺血性心肌的能量代谢障碍、心血管损伤的修复等机制以及早期干预等相关研究领域取得了一系列创新性科研成果。近五年来，本群体在Circulation、Circ Res、JACC、ATVB、Stem Cells、Hypertension、Cardiovasc Res等著名杂志发表论文200余篇，研究成果被Lancet、JAMA, Nature, Circulation等杂志引用1700余次，并获得国家科技进步二等奖、国家技术发明二等奖等。

Ischemic cardiovascular diseases have been leading risk factors which contribute greatly to the increase in morbidity and mortality in China as well as in the world. However, the pathologic and the molecular mechanisms of how ischemic cardiovascular diseases develop remain largely unknown, resulting in the lack of the effective methods of prevention and treatment. We have worked together on the basic and translational research on ischemic cardiovascular diseases for more than ten years, especially on the mechanisms of ischemic cardiovascular diseases such as the inflammatory mechanism of cardiovascular remodeling, the mechanism of microvasculature injury, the metabolic mechanism of myocardial ischemia and the mechanism of cardiovascular protection, etc., and obtained a variety of innovative achievements. In the past five years, we have authorized more than 200 papers published in Circulation, Circ Res, JACC, ATVB, Stem Cells, Hypertension, Cardiovascu Res, etc., which have obtained more than 2000 citations.