精神分裂症是一种严重的易反复发作的精神疾病，大部分病人需要长期、甚至终生服用抗精神病药物，而抗精神病药物引起两大非常棘手的副作用是代谢综合征和内分泌紊乱，目前尚无有效的防治方法。申请者从事抗精神病药物引起的代谢综合征和内分泌紊乱的防治对策的研究，第一次报道二甲双胍联合生活方式干预能有效治疗抗精神病药物引起的代谢综合征和内分泌紊乱，提出胰岛素抵抗在其中起着非常重要作用的新观点。发表第一作者、通讯作者SCI论文11篇，其中IF值大于10的4篇，包括JAMA（IF值=31.718）1篇，Molecular Psychiatry（IF值=14.496）1篇，Am J Psychiatry（IF值=14.721）2篇，总IF值为95.297，总他引次数378次。获中国百篇最具影响国际学术论文、吴孟超医学青年基金二等奖及湖南医学科技一等奖（排名第2)，入选2014年中组部“万人计划”青年拔尖人才。

Schizophrenia is a serious and recurrent mental disorder. The majority of patients have to take the antipsychotic for long time even lifetime. Antipsychotic drugs could induce two very tricky side effects: metabolic syndrome and the dysfunction of endocrine. However, there were not effective treatment methods for antipsychotic-induced metabolic syndrome and endocrine dysfunction. Majoring in the treatment of antipsychotic- induced metabolic syndrome and endocrine dysfunction, we firstly reported that metformin and lifestyle intervention were effective in improving antipsychotic- induced metabolic syndrome and endocrine dysfunction, and got a new idea that insulin resistance played a key role in the antipsychotic-induced metabolism syndrome and the dysfunction of endocrine. As the first author and corresponding author, I have published 11 SCI papers including 4 papers that the impact factor (IF) was more than 10,including 1 from JAMA (IF=31.718), 1 from Molecular Psychiatry (IF=14.496) and 2 from Am J Psychiatry (IF=14.721). The total IF of the eleven SCI articles is 95.297 and the total citations are 378. One of them was granted as a top one hundred most cited Chinese papers published in international journals. I received the second-class reward in Wu Mengchao Medical Youth Fund, the Organization Department of China “ten thousand plan” Outstanding youth talents and the first prize of Hunan Medical Science (ranked 2nd). All the results provide a new idea for the treatment of antipsychotic-induced metabolic syndrome and the dysfunction of endocrine, and provide theory evidences for further study of the mechanism.