申请人长期从事急性缺血性卒中再通治疗的研究，并着重开发新型影像标记物在预测急性再通和出血转化中的应用。已在Neurology、Stroke和JNNP等国际期刊以第一或通讯作者发表SCI论文41篇，合计影响因子171分，他引达718次，受到国际同行广泛关注。主要成果为：1. 在国际上率先利用动脉内血栓的影像特征预测再通；2. 在国际上创新性发现多项再通后出血转化的预测指标，以及中国人群再通获益的影像定量标准，形成全面的获益/风险评估系统；3. 率先利用影像证实颅内静脉在脑小血管病中的作用。本项目将在前期工作的基础上，创新性利用新型影像技术明确颅内静脉在再通后再灌注损伤中的作用，以全新的视角阐明再灌注损伤机制，全面反映动脉再通、组织灌注和静脉回流这一整合过程。预期研究结果有助于建立急性再灌注损伤的影像分析技术，并利用影像技术预测再灌注损伤，筛选最可能从早期再通中获益的人群，达到个体化治疗目的。

The applicant has committed herself to clinical scientific research for a long time in the field of acute treatment of ischemic stroke, focusing on exploring imaging markers for predicting recanalization and hemorrhagic transformation after reperfusion therapy. She has published 41 papers in the international leading journals, including Neurology, Stroke, and Journal of Neurology Neurosurgery & Psychiatry, as first or corresponding author. Total impact factor is approximately 171. These papers have drawn exceptional attention from international peers and have been widely cited by different journals for more than 700 times. Her major achievements are: 1. To improve treatment decisions of endovascular treatment based on the novel knowledge of neuroimaging as a biomarker of responsiveness to Alteplase. 2. To identify the risk–benefit ratio of reperfusion therapies using imaging parameters to determine the optimal thresholds of ischemic penumbra and infarct core based on Chinese population, and develop prognostic markers of hemorrhagic transformation after thrombolysis. 3. To explore the venous mechanism of cerebral white matter hyperintensities by utilizing the advanced imaging modalities. Based on these earlier work, this project will further explore the role of morphology and function of intracranial veins in cerebral postischemic reperfusion injury after recanalization therapy for acute ischemic stroke patients, which will help to establish robust clinical imaging measurements of reperfusion injury, identify prognostic image markers and assist treatment and prevention of reperfusion injury, finally leading to proposals for identifying an enriched population of patients with the potential for a major clinical response to early recanalization.