根性神经痛是椎间盘突出继发神经根损伤后最主要的临床症状，病程缠绵难愈，严重影响患者的身心健康。炎症反应是根性神经痛的病理基础，COX-2/PGE2信号通路是调控根性神经痛的重要信号通路；NF-κB是调控炎症反应的关键转录因子，参与神经炎性病变和神经病理性疼痛以及神经根损伤后的多种功能改变，已成为炎性疼痛的治疗新靶点。.本项目组前期研究证实芪麝丸具有降低神经根炎性物质含量、改善神经元细胞形态与超微结构、抑制神经元细胞凋亡、缓解根性神经痛的作用，但其调控机理尚未明确。本项目进一步利用颈神经根受压动物模型，从NF-κB与COX-2/PGE2信号通路探讨芪麝丸在根性神经痛的发生、发展和信息传递过程中的重要作用和分子机制；阐明该药临床治疗根性神经痛的有效性与科学性，为临床治疗炎性疼痛提供新的方法和思路。

Radicular pain is the most common clinical symptom of herniated disc,seriouslyaffect the patient's physical and mental health.Inflammation is the Pathologicbases of radicular pain.COX-2/PGE2 signal pathway is an important signal pathway regulation of radicular pain.NF- kappa B is the key transcription factor regulating inflammation,Participate in neuritic lesions and neuropathic pain, has become the new treatment target of inflammatory pain..This project studies confirmed the Qishe Pill can reduce the nerve root inflammation substance content, improve the neuronal cell morphology and ultrastructure, inhibiting neuronal apoptosis, relieving radicular pain effect, but the mechanism is not clear. On the basis of the preliminary studies, we use nerve root compression animal model, To explore the effect and molecular mechanism of NF- kappa B and COX-2/PGE2 signal pathway in the transfer process of radicular pain occurrence, development and information. and indepth study Qishe Pill mediated the NF- kappa B and COX-2/PGE2 signal pathways to Relieving radicular pain,To provide new ideas for clinical treatment of inflammatory pain.