申请人主要致力于认知功能障碍相关疾病，尤其是AD的发病机制研究，取得了一定的研究成果：①首次在清醒动物中证实NMDA受体不同亚型和AMPA受体转运在突触可塑性（LTP和LTD）中的作用，并进一步研究发现了记忆巩固和记忆增强的海马LTD机理，为阐明学习记忆的突触可塑性机制提供了重要证据；②研究发现了记忆衰退的细胞分子机制，并证实抑制AMPA受体内吞介导的LTP衰减可以改善AD小鼠的认知功能，为临床治疗AD提供了新的思路和方法。共发表论著32篇，其中2010年回国后，以第一和通讯作者在JCI等期刊发表SCI论文11篇；主持参加973和NSFC等课题多项；参研项目获重庆市科技进步一等奖和教育部科技进步二等奖；入选重庆市青年拔尖人才，获重庆市青年科技奖和十佳科技青年奖。申请人拟在先前研究成果的基础上，进一步探索：以认知功能障碍为主要临床表现的AD的发病机理，为临床防治这类疾病提供新的靶点和依据。

The applicant conducted extensive research on the pathogenesis of cognitive diseases, especially Alzheimer's disease (AD), and has made several novel discoveries. First, the applicant validated for the first time the different roles of NMDA receptor subtypes and AMPA receptor trafficking in synaptic plasticity, including the long-term potentiation (LTP) and long-term depression (LTD), in freely-moving animals, and proved the hippocampal LTD mechanisms underlying the consolidation and enhancement of long-term memory, providing critical evidence for the synaptic plasticity mechanisms underlying learning and memory. Second, the applicant reported the cellular and molecular mechanisms of memory loss, and validated that the inhibition of AMPA receptor endocytosis-mediated LTP decay ameliorated cognitive functions in a murine model of AD, offering potential insights and methods for clinical treatment of learning and memory disorders such as AD. To date, the applicant has published 32 peer-reviewed research articles. Eleven of them were published after the applicant established his independent research team in the Children’s Hospital of Chongqing Medical University in 2010, and appeared in high impact SCI-indexed journals such as JCI with the applicant being the corresponding authors. Currently, the applicant is taking charge of several National Natural Science Foundation of China (NSFC) and Chongqing Science and Technology Commission (CSTC) research projects, and also participating in 2 "973 Program" of the Ministry of Science and Technology of China as academic backbone, 3 of which were already completed. The research projects in which the applicant participated won the first class of "Chongqing Scientific and Technological Progress Award" in 2013 and the second class of "Ministry of Education Science and Technology Progress Award" in 2012. Furthermore, the applicant was selected in the first "Chongqing Youth Talent" support program in 2013, the eighth "Chongqing Youth Science and Technology Award" in 2014 and the first "Top Ten Youth Award for Science and Technology" in 2015. Based on the previous work, the applicant plans to further explore the cellular and molecular mechanisms underlying the pathogenesis of AD that is characterized by cognitive impairment, and ultimately provide new targets and theoretical basis for the clinical treatment of such neurodegenerative disorders.