申请人多年来致力于痛觉调控及离子通道机制研究。自2009年回国建立实验室以来，主要开展了以下两方面工作：1）偏头痛发病及离子通道调控; 2）低电压激活通道在慢性痛中作用。申请人关于上述研究结果近五年来以通讯作者在Journal of Pineal Research（IF：9.6），Science Signaling（Science子刊，封面文章，IF：6.27），J Biol Chem，Endocrinology及Biochem Pharmacol等杂志上发表SCI收录论文12篇。偏头痛是一类机制未明的三叉神经血管系统疾病。我们实验室长期目标在于揭示偏头痛环路关键神经元功能调控及相关离子通道机制。本项目将阐明中枢三叉神经尾核背角神经元参与偏头痛发生的细胞及分子机制。研究结果将有助于发展和完善偏头痛的病因学说，并为研发理想的偏头痛治疗药物提供新的分子靶标。

The applicant has been working in the field of the regulation of ion channels in pain and its relevant mechanisms. Since the applicant full-time to return in 2009, his lab is mainly engaged in basic medical research content of the following two aspects: 1) ion channel mechanisms of migraine; 2) receptor signal transduction of low-voltage T-type calcium channel and its roles in pain regulation. In the past five years, as the first corresponding author (full domestic work), he has published 15 research articles in the prestigious international journals including: Journal of Pineal Research (Impact factor 9.60)，Science Signaling (cover story, Impact factor 6.27), J Biol Chem, Endocrinology and Biochem Pharmacol, etc.. Migraine is one of the most common periodically neurological disorders. However to date, the underlying mechanisms remain largely unclear. The long-term research interest of our lab is to study the ion channel mechanism of migraine. This study will reveal the cellular and molecular mechanism of migraine and provide potential therapeutic targets for the clinical treatment of chronic migraine.