光学活性农药分子是植物保护领域新农药研究开发的前沿和重要发展方向之一。本项目结合立体有机化学的原理和农药分子设计的理论和植物保护的规律，针对我国重大病毒病害，基于植物系统获得抗病性和具有诱导抗病活性的亚结构单元，设计合成具有光学活性的噻唑类绿色农药先导分子及其衍生物，并引入哌啶环以调节目标分子的理化性质和成药性，引入具有诱导抗病活性的亚结构单元，充分利用植物自身的系统获得抗病性，提高植物保护的效率，同时减少农药的用量，保护农业生态环境；对高活性化合物进行系统的生物活性筛选和构效关系的研究，从农药环境毒理学的角度阐明前植物激活剂的原理。利用甲噻诱胺和本申请发现的高活性分子以microRNA技术开展诱导抗病作用机制的研究和作用靶标的探索。研究结果对我国重大病毒病害的综合防治和新农药创制以及植物保护具有重要的理论意义和实践价值。

Optically active molecules with specific biological activity are the frontier and an important direction of novel pesticide development in plant protection, on the basis of systemic acquired resistance and substructures with induction activity, aimed at the key virus causing disease in China, novel optically active thiazole containing green pesticide leads and their derivatives were designed and sythesized by combination of theories of organic stereochemistry, pesticide molecular designation and principles of plant protection, piperidine is introduced to improve the pesticidability and physicochemical properties of the target molecules. Sbustructures with systemic acquired resistance are introduced to improve the effecacy of the plant protection and decrease the pesticide application for the agroenvironment protection by taking full advantages of plant innate systemic acquired resistance. The biological activities of all the novel target compounds will be screened for structure activity relationship studies. Studies on the elucidation of pro-elicitor is conducted according the principles of pesticide environmental toxicology. The mode of action and the target of the plant elicitor methiadinil and the highly active target compounds discovered in this proposal are stduied by microRNA researches.The results of this proposal will have important meanings to the integrated key virus disease control and make great contribution to the novel pesticide development and plant protection in theory and practice.