肺与大肠相表里是藏象中脏腑相关理论的重要内容，在外感热病的疾病传变中，肺与大肠相关联以及反馈调节机制的现代内涵尚不明确。本课题组已证实流感病毒感染不仅引起肺损伤，同时也造成了肠道损伤。由于肺与肠在胚胎发育上有共同起源，肠道菌及肠道粘膜免疫系统在肺肠疾病相互作用中扮演重要角色，因此推测肠道粘膜免疫系统在流感的多组织损伤机制中发挥了关键作用。本研究拟从肠道菌群及肠道免疫两个角度来探求流感病毒诱导肺-肠损伤的作用机制，并运用肺经药鱼腥草以及肺肠同治验方宣白承气汤作为工具药验证以肺肠表里理论为指导的药物对流感病毒诱导的肺肠组织损伤的保护机制，揭示流感中肺与肠在疾病传变中的反馈及药物干预机制，阐明肺肠表里理论的现代内涵，为中医药在病毒性疾病中广谱治疗优势提供现代依据。

The theory of lung and gut being interior exterior is the important part of the theory of visceral outward manifestation, but how to being pathogenesis transmission from lung to gut in the infectious disease, is not clear. The results had showed that lung injury and gut injury could be induced by influenza A virus simultaneously. Lung and gut have a common embryonic development, and gut microbiota and intestinal mucosal immunity would regulate the relationship between the lung and gut in physical and pathological process. So, we speculated that intestinal mucosal immunity exert the crucial effect on the lung and gut injury. We aims to study the mechanism on lung-gut injury induced by influenza A virus based on gut microbiota and intestinal mucosal immunity. So, Houttuynia cordata and decoction of xuan-bai-cheng-qi as tool medicine, would be verified the protective mechanism on lung-gut injury induced by influenza A virus, which under the guidance of the theory of lung and gut being interior exterior. The research would reveal that the mechanism on pathogenesis transmission from lung to gut in influenza, which would clarify that modern connotative definition on the theory. The prospective results would provide the evidence on the superiority of the treating infectious diseases intensively with Chinese medicine.