脂质代谢紊乱和慢性炎症反应是冠心病核心的病生理机制之一，PPARs-PGC1α通路因可同时调控上述机制而成为领域研究的焦点。丹七片对冠心病确有疗效被列入2010中国药典，但对其研究集中在抗血小板凝聚和改善心功能上。本课题组前期基于整方率先报道了丹七片对冠心病脂代谢和炎症的调控作用，但机制是否通过PPARs-PCG1α介导、相应的调控机制和物质基础均未见报道。本课题以丹七片为工具药，全面筛选PPARs-PCG1α通路调控脂质代谢和炎症通路效应蛋白，基于效应蛋白化学结构，采用分子docking、BATMAN等方法反向钓取起效中药成分，应用ADMET技术筛选成药性好的中药分子，构建并分析药-靶对映关系属性，结合整体/离体实验验证，最终阐明起效成分明确、作用靶标清楚的丹七片协同增效、治疗冠心病的机制。本课题对揭示丹七片药理机制与作用物质基础、中药精制与二次开发国际认可的冠心病治疗药物意义重大。

Lipid metabolism disorders and chronic inflammation responses are the core of the physiological mechanism of coronary artery disease (CHD), PPARs-PGC1α pathway can regulate them simultaneously, and thus, the pathway becomes the focus of the field. Danqi pill was included in the Chinese Pharmacopoeia 2010 because of its definite efficacy on CHD, but more studies were focused on its anti-platelet effect and improvement on the heart function. In our previous study, we reported the efficacy of Danqi pills on lipid metabolism of CHD and inflammation based on the formula for the first time, but whether its pharmacological mechanism is mediated by PPARs-PCG1α pathway, the exact active components as well as the corresponding multi-targets are rarely reported. In this research, Danqi pill is used as tool drug, animal experiment is adopted to screen the potential targets or pathways comprehensively. Docking and SPACE methods et al. are employed to obtain the corresponding components reversely which based on the molecular structure. Then ADMET is used to screen the high druglikeness of the molecules containing in Chinese herbs. Drug-target regulatory networks are constructed and analyzed subsequently. After that, the relationships between drugs and targets are to be confirmed through the vitro and vivo experiments. Finally, synergistic effects and treatments of Danqi pills on CHD are clarified, which have clear components and targets. The project has important significance in proposing new treatment ideas and intervention aspects of CHD, comprehensively revealing the acting characteristics of Chinese herbs of multiple components, multiple targets, even has promising prospects on promoting the new drugs for CHD in clinical applications.