申请人近十年专注于运动系统疾病临床工作、遗传学和再生研究。根据骨关节炎遗传学特质和软骨修复的基础应用研究方面进行了一系列研究。相关工作发表59篇文章。平均影响因子4.39，SCI他引830次，单篇最高209次，H指数12，其中42篇为近5年文章。其中第一作者、共同第一、共同通信共19篇（平均影响因子4.26）。主要创新：1，发明了软骨修复方法，将含有纳米包裹小分子有机物的液态支架填充于软骨缺损处，紫外照射30秒后形成固体支架。药物持续缓释2个月修复缺损软骨。最终获得组织学，形态学，生物力学接近于天然软骨。本技术具有一次微创关节镜手术（一步法），缓释药物持续久，利用自体原位细胞，且再生软骨接近天然等特点；2，发现了骨关节炎、髋关节发育不良多个致病基因。本项目拟进一步探索小分子有机物修复软骨及寻找相关致病基因，以筛选软骨损伤高危人群及简单有效的治疗方法。

The applicant has committed himself to clinical work and scientific research for 10 years in sports system. Based on genetic background of osteoarthritis and pathology of cartilage injury, he launched a series of research and published 59 papers (59 total, average IF is 4.39, 456 times cited, H index 12). 19 of which are finished as first, or co-first and co-corresponding author (average IF is 4.26). His major achievements are:1, invented a simply way for cartilage repair. The effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology. In vivo studies showed its potential role for cell homing, especially for recruiting the host’s endogenous cells, including BMSCs and SMSCs, without cell transplantation. Of note, the regenerated tissues were close to the natural hyaline cartilage based on the histological tests, specific markers analysis and biomechanical tests. This innovative KGN release system makes the chondrogenesis efficiently and persistently; 2, discovered several disease-causing genes for osteoarthritis and hip dysplasia. Based on previous work, to find population with high risk and more effective threpautic strategy, this project will explore new small moelcular compund and search for new susceptible genes for cartilage related disease.