申请人从事植入性医疗器械尤其是脊柱、关节器械的基础研究，以临床需要为入口，以产品转化为出口，取得如下创新性成果：1、自主研制淀粉重结晶增强的磷酸钙可注射椎体成型剂，获中国创新创业大赛全国第二名并受邀向刘延东总理汇报创新产品；2、率先报道纳米晶金刚石由表面拓扑和自由能调控的骨传导性，开发人工关节用纳米晶金刚石涂层，凭此获美国三大研究学会（MRS、SFB 、Sigma Xi）的最高博士生奖；3、首次确定钽氧化物场致结晶的微钠尺度机制，贡献于提升美敦力EveraS产品25%的寿命；4、自主研制降解可控的羟基磷灰石，转化后头年即形成销售42.4万元。此外，总计申请发明17项，发表论文36篇。独立工作三年来，申请发明13项、已授权6项及PCT1项，由Elsevier出版个人英文专著1部，发表论文14篇。未来拟通过自行设计高分辨原位即时测量系统对植入物／骨界面的力学与生物学耦合适配问题展开研究。

The applicant’s research experiences focus on fundamental problems of medical implants especially for spine and joints, with emphases on fulfilling clinical demand and product-oriented innovations. His research outcomes include four main directions. 1. He invented injectable kyphoplasty cement reinforced by gelatinized starch, whose prototype secured him the 2nd place in the 4th China Innovation and Entrepreneurship Competition. He was also proudly selected to report his innovation to China Vice-Prime Minister Liu Yandong. 2. The applicant was among the first ones who reported the topographical and surface energetic effects of nanocrystalline diamond (NCD) on implants’ osteo-conductive properties, and has also developed NCD coating for Ti-based orthopedic implant. Based on his discovery and innovation, he has been recognized by three top-tier PhD awards from MRS, SFB and Sigma Xi, respectively. 3. His research on field-induced crystallization in amorphous Ta oxides unveiled the multi-scale crystallization mechanisms for the first time, which helped to improve the longevity of Medtronic EveraS up to 25%. 4. His has developed biodegradable hydroxyapatite, whose derivative product resulted in sales of 424k RMB in 2015. Besides translational innovations, the applicant has published 36 SCI/EI papers and 17 patent applications. Since he turned into a PI three years ago, he has published a monograph with Elsevier, 14 papers and 13 patent applications with 6 approved and 1 PCT. In terms of future plan, the applicant will first develop a new research tool based on a real time, in situ device that simultaneously measures strain and fluorescent signals at the implant-bone interface. Results from such measurements will be used to construct a coupling model describing the synergetic effect of mechanical matching and biological coordination. Simulation and verification results are expected to provide new insights and data to the design and development of orthopedic implants with improved efficacy.