耐甲氧西林金黄色葡萄球菌（methicillin-resistant Staphylococcus aureus，MRSA）是医院感染和社区获得性感染的重要病原菌，MRSA感染可威胁患者生命。随着多重耐药谱扩大，开发新的抗菌治疗方法迫在眉睫。光动力抗菌化学疗法是一种新兴的、具有发展前景的治疗策略，通过特定波长的光源激活特异的光敏剂产生活性氧等细胞毒性物质，高效、选择性地杀死细菌。具有杀菌范围广、安全性高、不易产生耐药性等特点。目前的光敏剂存在特异选择性低、组织光毒性较大等问题，本研究拟在课题组前期工作基础上，采用纳米高分子聚合物修饰并运载对MRSA表达的β-内酰胺酶敏感的光敏剂，研发具有高效、高特异性、低副作用的高分子聚合物运载光敏剂，用于抗创面MRSA感染的光动力学治疗。为临床抗MRSA感染患者治疗提供有力工具，并可为其他耐药菌光动力学治疗的研究提供新思路。

In recent years, methicillin-resistant Staphylococcus aureus (MRSA) has become one of the most common multi-drug resistant bacteria in both hospital and community, which is a critical threatening to patients. Infection due to MRSA imposes a high and increasing burden on health care resources in most countries. As the multi-drug resistance grows, patients with MRSA infection are usually difficult to treat due to limited therapeutic options. Therefore it is necessary to continuously search for alternative methods against MRSA towards which no resistance can develop so quickly. One of the most promising and innovative approaches in this respect is antimicrobial photodynamic therapy, which generates cytotoxic reactive molecules and kills microorganisms by combining photosensitizer, light of appropriate wavelength, and oxygen. However, most of current photosensitizers have toxicity to normal tissues due to the low selectivity for targeted microorganism. The aim of this study is to investigate the selective inhibition of MRSA efficiently by a polymer-carried photosensitizer based on our preliminary data, which could supply an effective way for the treatment of MRSA infection in clinic and inspire the research on other multi-drug resistant bacteria.