近年来，随着我国社会生活水平的提高，小儿厌食症呈上升趋势，引起了医学界的广泛重视。中医药在治疗小儿厌食症方面积累了丰富的经验，关于厌食症的机理研究主要集中在蛋白组学、免疫组学等方面，但对于肠道微生态学研究国内仍少见报道。研究发现肠道微生态结构失调是厌食症发生和发展的关键因素。本项目拟在前期研究基础上，以病因模拟法制备的厌食症模型大鼠为研究对象，将本病的中医病机实质、肠道微生态稳态及中医“脾主运化”理论三者结合起来，以此为切入点，首次采用目前最先进的PCR-DGGE法及1H NMR的代谢组学等分子生物学技术，探讨运脾消积法对厌食症模型肠道微生态及宿主代谢表型的影响，诠释该法的内在机理，丰富以运脾消积法为代表方的小儿开胃增食合剂治疗厌食症的科学内涵，提出和发展治疗厌食症的新思路和新途径。

In recent years, with the improvement of living standards of our society, the incidence of anorexia upward trend, this phenomenon has aroused wide attention of the medical profession.TraditionalChinese medicine in the treatment of anorexia in children has accumulated a wealth of experience, mechanism study focused on anorexia in proteomics, immune proteomics etc, but for the intestinal microecology in domestic research is still rarely reported. The study found that structural imbalance of intestinal microflora is a key factor in the occurrence and development of anorexia.On the basis of the preliminary study, the project in the etiology and simulation preparation of anorexia rats as the research object, the TCM pathogenesis of essence of anorexia, intestinal micro ecological homeostasis and traditional Chinese medicine"the spleen's governing transportation theory " the three combined,to these as athe breakthrough point, for the first time using the most advanced method of PCR-DGGE and 1HNMR metabonomic studies of molecular biology techniques of Yunpi Xiaoji method about anorexia model of intestinal micro ecology and host metabolic phenotypes of influence.The internal mechanism of interpretation of the law, rich scientific connotation of Xiaoer kaiwei ZengShi mixturewhich is the representative of the yunpi xiaoji method in the treatment of anorexia, and put forward new ideas and new ways for the development of the treatment of anorexia.