申请人主要从事放射性皮肤损伤的的机理与治疗研究，先后发现了两种能介导大分子蛋白质透皮的结构域；将多种功能蛋白质进行透皮结构域修饰后成功应用于放射性皮肤损伤治疗；从皮肤细胞应激调控网络角度揭示了放射性皮肤损伤进展的新机制。近五年作为第一发明人获国家发明专利两项，发表SCI 论文48篇，总影响因子超过150，他人引用270余次。第一作者和/或通讯作者SCI论文24 篇（均为国内开展完成），最高影响因子为8.56，影响因子>5分8篇。部分研究成果被加拿大Global Medical Discovery网站以关键科学论文报道。两次获得全国放射医学与防护青年学术交流会一等奖；作为主要完成人获省部级二等奖两项。拟开展脂肪酸微环境调控能量代谢影响电离辐射后皮肤重建与纤维化的机制研究，从脂肪酸微环境与皮肤细胞相互作用的角度揭示放射性皮肤损伤进展的新机制，为其防治提供新的策略。

The applicant is mainly engaged in exploring the mechanisms and countermeasures for radiation-induced skin injury. The applicant has found two protein domains that can mediate the penetration of large molecular weight proteins into skin epidermis and dermis. Based on these domains, modified antioxidant enzymes can be delivered across the skin and protect skin against ionizing radiation, which provides novel strategies for this injury. Moreover, the applicant has also illustrated a new mechanism driving radiation-induced skin injury. In the past five years, the applicant has acquired two inventary patents and published 48 SCI-based papers. These papers have a total impact factor of over 150 and have been cited over 270 times. The applicant is first author and/or corrresponding author for 24 of the above published papers, which are all carried our in domestic laboratory. Among the first author and/or corrresponding author papers, eight papers have over 5.0 impact factor, with the highest impact factor up to 8.56. A part of the reaserch was reported by Canadian Global Medical Discovery website as a Key Scientific Article. The applicant has been twice awarded national youth prize in radiation medicine and protection conference and two provincial and ministerial level awards as a major participant. The applied project will focus on the influence of free fatty acid microenvironment on the skin restruction and fibrosis after ionizing radiation. This project will investigate the interplay between energy metabolism regulated by free fatty acid microenvironment and skin cells, which is likely to illustrate the important role of energy metabolism in recovery and fibrosis of radiation-induced skin injury and provide novel therpeutic measures against this disease.