血管平滑肌细胞表型的改变是血管结构异常所导致的心脑血管病的病理基础，药物干预血管平滑肌细胞表型调控成为血管病变治疗新的切入点。蒙医学理论认为“热灼脉壁或浊入血分”是脉管失调的关键病机。我们前期研究发现蒙药白益母草总生物碱可抑制血管内膜增厚，维持血管平滑肌细胞收缩表型。基于此，在蒙医学理论指导下，本课题将从血管病变发生、发展的核心病机—脉壁入手，确证白益母草总生物碱对血清炎症水平（CRP、IL-6、TNF-α）和NADPH Oxidase-ROS介导的血管平滑肌细胞表型转变的干预效应，揭示其通过转录因子Myocardin、SRF调控收缩表型特征蛋白 α-SMA、SM MHC、SM 22α表达的机制，探寻白益母草总生物碱干预表型调控的关键节点。以此为依据，判断血管平滑肌细胞表型调控关键节点的药物靶向可行性，为血管病变性疾病治疗提供新的思路。丰富以“三根”为治则的蒙医药理论的科学内涵。

Cardiovascular disease has been the primary cause of mobidity and motality for human life. Dysfunction and constructional heterization of vascular is the principle of initiation and progress in the disease. According to theory of Mongolian Medicine, the critical mechanism of the disease is “hot injurys vascular, or filth permeates into blood”, which results in disorders of vasculature. The symptoms are conformity with atherosclerosis and hypertension. Our research indicated that total alkaloids of Mongolian herbal Panzeria alaschanica Kupr. with effects of promoting blood and stasis- resolved, prevented myocardial ischemia induced by isoproterenol on rats, and inhibited intimal hyperplasia on mice. It kept vascular smooth muscle cell contractile phenotype subjected to low serum and PDGF-BB. Based on advanced investigations and Mongolian medicine theory, this project aims at critical factors, focuse on “vasculture”, testifying the effect of alkaloids on inflammatory factors in serum and the regulation net of vascular smooth muscle cell mediated by NADPH Oxidase-ROS. Clarifying the regulation mechanism of the characteristic proteins (α-SMA, SM MHC, SM22α) expression of vascular smooth muscle cell by phenotypes regulatory transcription factors (mycardin, SRF). Verifying critical points in the phenotype regulation signal cascade. Based on above evidences assess the potential target for new drug discovery of cardiovascular diseases. Likewise complement “three principle roots” of Mongolian Medicine with scientific explanation.