申请人长期从事神经影像学医疗和科研工作，运用磁共振脑功能成像技术，重点围绕“脑功能连接的生物学意义”开展研究。申请人发现脑功能连接的个体差异具有脑网络、脑进化依赖性，并与人类行为密切相关，证实功能连接具有明确的生物学意义，为理解个体能力的多样性、预测疾病的个体易感性、制定个体化治疗方案提供理论依据；开创性提出利用“桥脑梗死”这种单一神经回路受损的临床疾病模型，进一步证实解剖是功能连接的结构基础，揭示了功能连接与患者临床预后的脑神经机制；这些成果为研究神经科学及临床问题奠定基础。在此基础上申请人运用脑功能成像技术解决临床关键问题：探索早期准确诊断脑缺血半暗带的成像技术、揭示常压高浓度氧对脑缺血的保护机制及针刺治疗痴呆的作用机制。申请人发表SCI文章35篇，其中第一或通讯作者12篇，单篇最高影响因子15.982，SCI他引428次。申请人拟进一步开展脑梗死后运动功能网络动态重塑的fMRI研究。

The applicant has been actively pursuing frontier basic and clinical neuroimaging studies. We have elucidated the intricate relationship between brain functional connectivity and polysynaptic pathway using magnetic resonance imaging techniques. The main research accomplishments include: (1) We have investigated the intersubject variability in connectivity using resting-state functional MRI (fMRI). This study provides a possible linkage between the diversity of human abilities and evolutionary expansion of specific brain regions. The finding is important for interpreting results from functional connectivity studies because conventional brain imaging studies often average data from multiple subjects, an approach that might mischaracterize regional differences. In addition, as clinical practice moves ever closer to the goal of individualized diagnosis and therapy, knowing the distribution of individual differences in brain connectivity is likely important. (2) We have demonstrated that functional connectivity between the cerebral cortex and the contralateral cerebellum is disrupted after the pons infarct. Our study further investigated functions of the cerebelllar intrinsic connection within the whole brain networks. The results provide direct evidence that functional connectivity depends on intact connections within a specific polysynaptic pathway. The results also raised the possibility of using functional connectivity, as a clinical measure, to study behavioral impairment and predict recovery. (3) On the basis of our prior work, we applied functional MRI technique to address key problems: development of novel techniques for accurate diagnosis of cerebral ischemic penumbra, study of the protective effect and mechanism of normobaric oxygen (NBO) in acute ischemia and mechanisms of acupuncture for treatment of dementia. The applicant has published 35 SCI papers in total, which have been cited 428 times, being the first author or corresponding author for 12 articles, including Neuron, Journal of Neuroscience, and Neuroimage, etc. Among these papers, the highest impact factor is 15.982. The applicant intends to apply fMRI study to monitor reorganization of cerebral networks after cerebral infarction with impaired motor function.