申请人主要从事肝脏移植的临床及免疫治疗的转化研究。主要成绩：1. 首次跨越调节性T细胞（Treg）诱导和扩增障碍，并将该技术应用于肝移植后的免疫诱导治疗。体外诱导和扩增Treg机制的研究论文获F1000评8分。目前已实施8例肝移植术后Treg免疫诱导治疗。成果发表在PNAS等。2. 首次系统分析ER-stress信号通路参与肝脏缺血再灌注损伤（IRI）的机制，并结合临床实际采取干预策略，研发了体外肝脏保存的循环支持系统。成果发表在Am J Transplant等。上述研究累计发表第一作者/通讯作者（兼共同）SCI论文32篇，他引273次。入选爱思唯尔2014中国“高被引学者”医学类榜单。拟开展研究旨在探讨miRNA-mRNA调控网络对nTreg功能的影响，为扩大Treg临床应用成果奠定基础！

The applicant’s research efforts mainly focus on liver surgery, liver transplantation and translational research of clinical immune therapy. Major achievements are as followings: 1) Applicant combined fundamental research on regulatory T cells (Tregs) and immune induction therapy after liver transplantation for the first time (F1000 score 8). In order to settle the obstacles that Tregs were scarce in vivo and functionally unstable after expansion in vitro, applicant first reported the method of inducing Tregs in vitro using TGF-βand its signal pathways. Up to now, eight patients have successfully received Treg therapy to induce immune tolerance after liver transplantation. Relevant papers were published on PNAS et al. 2) Applicant first systematically studied the signaling pathways of endoplasmic reticulum stress (ER-stress) in liver ischemia reperfusion injury (IRI) and the clinical intervention strategies. Liver graft circulatory support system was investigated and developed to suppress ER-stress, thus improving the quality of liver graft. Three ER-stress pathways during liver IRI were systematically studied to develop possible intervention strategies. Research results were published on Am J Transplant. During the research, 32 papers were published in SCI-indexed journals, and total non-self citations are 273 . Applicant also achieved the honor of “Highly-Cited Chinese Researcher 2014” in the field of medicine released by Elsevier. Upon these foundations, further studies will be performed to analyse the impact of miRNA-mRNA regulatory network on the function of naturally occurring regulatory T cell (nTreg), and to find potential miRNAs which could be utilized for clinical use.