多年来团队开展突触传递的分子机制研究，在神经环路和突触可塑性的调控以及神经精神疾病的发病机制等领域的研究中形成了显著优势、作出了系统的创新性工作，已经入选教育部和浙江省神经精神疾病创新团队，核心成员包括中国科学院院士1人、何梁何利科学与技术进步奖获得者1人、973首席科学家2人、国家青年千人计划1人、国家杰出青年科学基金获得者1人、国家自然科学和科技进步二等奖获得者3人。本创新群体将综合应用现代医学、生物学、物理学的理论和技术，以突触网络调控的分子机制为切入点，深入研究精神疾病相关重要致病分子对神经环路和突触的发育、连接、结构修饰及功能调制的作用及机理，尤其是这些分子对不同神经环路、不同类型神经细胞和突触的差异作用，从而解析神经精神疾病的神经环路连接及其功能活动失衡的机制。群体协力攻关，为精神分裂症、孤独症和癫痫等重要神经精神疾病的发病机制、诊断和新药物靶点寻找提供新的靶点和思路。

The research team led by academician Duan Shumin is focusing on elucidating the molecular mechanism of synaptic transmission, and has made significant progress in understanding the regulatory mechanisms underlying synaptic plasticity and neural circuit formation, as well as the pothogenesis of neuropsychiatric diseases. The group has been selected as the innovation team of neuropsychiatric disease research by the Ministry of Education of the People's Republic of China and Zhejiang Province. The team includes 5 key members, who hold numerous honors, including an academicianship in Chinese Academy of Sciences, two chief scientist positions in National 973 Projects, one receipient of the National Science Foundation for Distinguished Young Scholars of China, one awardee of the National One Thousand Young Scholar Program, two winners of the National Natural Science Award Second Prize, one winner of the National Technological Award Second Prize, and one winner of the Ho Leung Ho Lee Advancement Prize. By using a combination of theories and technologies from modern medicine, biology, and physics, the innovation research group will investigate the mechanisms of differential synapse development and synapse modification, elucidating abnormal synapse and circuit formation in neuropsychiatric diseases. The group will tackle key problems in synapse malfunction and circuit mis-wiring in neuropsychiatric diseases such as schizophrenia, autism, and epilepsy to advance our understanding of the pathogenesis, diagnosis, and therapeutic targets of these disorders.