申请人从事细胞跨膜信号转导的研究，系统性阐明酸性磷脂对T细胞抗原受体（TCR）跨膜转导抗原刺激信号的调控机制。博士后工作发现酸性磷脂可通过静电效应屏蔽TCR的功能位点并研究TCR的组装机制（Cell，JBC，第一作者）。2009年底回国建独立实验室后，发现钙离子可以中和细胞质膜酸性磷脂的负电荷、消除酸性磷脂对TCR的屏蔽作用、促进TCR磷酸化从而帮助T细胞的活化（Nature，通讯作者）。合作研究酸性磷脂对其它膜蛋白的调控机制，发表共同作者研究论文5篇（Nat Med等）。受邀撰写酸性磷脂通过静电效应调控蛋白质功能这一新领域的综述（Trends Biochem Sci，通讯作者）。获中科院青年科学家奖等奖项，受邀担任Scientific Reports编委。博士期间在JBC等发表第一或共同第一作者研究论文5篇并获上海科技进步一等奖。今后重点研究磷脂和胆固醇分子对细胞跨膜信号转导的调控机制。

My long-term interest is to study the molecular mechanism of cross-membrane signal transduction. I have systematically studied the role of acidic phospholipids in regulating the cross-membrane signal transduction of T-cell receptor (TCR). My postdoctoral work studied TCR assembly and signaling (Cell, JBC, first author). I found that acidic phospholipids could sequester the functional sites of TCR within the plasma membrane through ionic interaction. After setting up my independent research program at the end of 2009, I found that Ca2+ could neutralize the negative charges of acidic phospholipids and disrupt the ionic TCR-acidic phospholipid interactions, thus facilitating TCR phosphorylation and helping T-cell activation (Nature, corresponding author). Through collaborations, I studied how acidic phoshpolipids regulate the function of other important membrane proteins, which led to 5 co-author research papers (Nat Med and others). I was invited to contribute a review summarizing the regulatory modes of protein function by acidic phospholipids (Trends Biochem Sci, corresponding author). I received several awards including the Young Scientist Award of Chinese Academy of Sciences and now serve as an Editorial Board member of Scientific Reports. During my Ph.D. study, I published 5 first or co-first author papers in JBC and other scientific journals, and received the First-grade Shanghai Municipal Science and Technology Award. In the future, I will continue studying the regulation of cross-membrane signal transduction by phospholipids and cholesterol.