病毒感染诱导的I型干扰素和炎症因子在宿主抗病毒免疫中发挥关键作用。申请人发现了病毒感染诱导I型干扰素表达过程中的多个关键接头蛋白和调控分子，包括VISA,WDR5,WWP2,HSC71和A20，为在分子水平诠释抗病毒天然免疫信号转导及其调控机制做出了实质性贡献；发现TRIM8及MIB1调控炎症因子激活NF-kappaB的机制，为解析炎症反应的调控机制提供了新的线索。这些工作在所在领域产生了重要的、持续性的国际影响。共发表SCI论文17篇，其中作为第一或通讯作者在PNAS发表论文3篇，在Mol Cell, Cell Host Microbe, Cell Res, FEBS Lett发表论文各1篇。论文累计被SCI他引1170次，其中第一/通讯作者论文被SCI他引795次。获得过中国免疫学会青年学者奖，入选万人计划首批青年拔尖人才。未来4年中，将用多种手段探索抗病毒天然免疫共性和特性机制。

Viral infection induces type I interferons (IFNs) and proinflammatory cytokines, which are critically involved in antiviral innate immunity and inflammation. The applicant identified critical signaling components and regulatory molecules in the virus-triggered signaling pathways leading to induction of type I IFNs and proinflammatory cytokines, including VISA, WDR5, WWP2 and A20. The applicant also revealed roles of the E3 ubiquitin ligases TRIM8 and MIB1 in signaling mediated by the proinflammatory cytokines TNF and IL-1. These discoveries contribute to our understanding of the molecular mechanisms of antiviral innate immunity and inflammation, and have made great long-lasting impact in this field internationally. The applicant has published 17 papers in international journals, including 1 in Mol. Cell, Cell Host Microbe and 3 in PNAS as a first/corresponding author. These publications have been cited for 1170 times by others. The applicant received the Young Scholar Award from the Chinese Society for Immunology, and was an awardee of the 10000 Talent Plan--Outstanding Young Talents. In the next 4 years, the applicant will investigate the common and distinct mechanisms of host antiviral innate immune responses against different types of viruses by using an array of divergent approaches.